摘要
目的:分析干扰素α-2b治疗小儿呼吸道合胞病毒毛细支气管炎的疗效及对患儿血清SP-D、TGF-β及IL-4水平的影响。方法:选取本院(在2017年1月至2019年10月)收治的120例呼吸道合胞病毒毛细支气管炎患儿,按照随机数字表法简单分为甲组(采用常规治疗方法)和乙组(在对照组基础上采用干扰素α-2b治疗方法),每组均为60例;再选取同期我院搜集的60例体检健康小儿作为对照组。比较患儿治疗之后的临床症状以及基础生命体征(发热、喘息、肺部啰音以及咳嗽等)消失时间、临床治疗总有效率,分析三组研究对象的血清SP-D、TGF-β及IL-4水平。结果:乙组患儿发热、喘息、肺部啰音以及咳嗽等消失时间显著短于甲组,差异比较有统计学意义(P<0.05);乙组的临床治疗总有效率显著高于甲组,差异比较有统计学意义(P<0.05)。单因素ANOVA方差分析结果显示,三组患者血清SP-D、TGF-β及IL-4水平差异具有统计学意义(P<0.05)。事后两两比较结果显示,甲组和乙组吸道合胞病毒毛细支气管炎患儿的血清SP-D及IL-4水平显著高于对照组,血清TGF-β水平显著低于对照组,差异比较有统计学意义(P<0.05);乙组患者SP-D水平显著高于对照组,低于甲组,TGF-β水平较对照组显著更低,IL-4水平较对照组显著更高(P<0.05)。结论:干扰素α-2b治疗小儿呼吸道合胞病毒毛细支气管炎的疗效显著,与此同时可显著降低患儿的血清SP-D、IL-4水平,提高TGF-β水平。
Objective:To analyze the effect of interferonα-2b on pediatric respiratory syncytial virus bronchiolitis and its effect on serum SP-D、TGF-βand IL-4 levels.Methods:120 children with respiratory syncytial virus bronchiolitis admitted to our hospital(from January 2017 to October 2019)were selected and divided into group A(using conventional treatment methods)and group B(on the basis of the control group,interferonα-2b treatment method was used),60 cases in each group;then 60 cases of healthy children were selected as the control group.The clinical symptoms and the disappearance time of basic vital signs(fever,wheezing,lung rales and cough,etc.)after treatment,and the total effective rate of clinical treatment were compared.The serum SP-D,TGF-βand IL-4 of the three groups were analyzed.Results:The disappearance time of fever,wheezing,lung rales and cough in group B was significantly shorter than that in group A,and the difference was statistically significant(P<0.05);the total clinical effective rate of group B was significantly higher than that in group A,and the difference was statistically significant(P<0.05).The results of single factor ANOVA variance analysis showed that the serum SP-D、TGF-βand IL-4 levels of the three groups were statistically significant(P<0.05).The results showed that the serum SP-D and IL-4 levels of bronchiolitis in group A and group B were significantly higher than those in the control group,and the serum TGF-βlevels were significantly lower than those in the control group(P<0.05).The SP-D level of group B was significantly higher than that of the control group,lower than that of group A,the TGF-βlevel was significantly lower than that of the control group,and the IL-4 level was significantly higher than that of the control group(P<0.05).Conclusion:The effect of interferonα-2b on pediatric respiratory syncytial virus bronchiolitis is remarkable,at the same time,it can significantly reduce the serum SP-D、IL-4 level and improve the TGF-βlevel of children.
作者
刘丹
杨显贵
高晓红
LIU Dan;YANG Xiangui;GAO Xiaohong(Anshan Central Hospital, Liaoning Anshan 114000, China)
出处
《河北医学》
CAS
2021年第1期89-92,共4页
Hebei Medicine
基金
国家卫生计生委医药卫生科技发展研究中心,(编号:W2016EAE118)。
