摘要
目的探讨孟鲁司特钠治疗小儿呼吸道合胞病毒(respiratory syncytial viruses,RSV)感染毛细支气管炎的疗效及对患儿血清半胱氨酰白三烯(cysteinyl leukotrienes,CysLTs)、嗜酸粒细胞阳离子蛋白(eosinophil cationic protein,ECP)水平的影响。方法选取2015年9月至2017年8月南京市中西医结合医院收治的102例RSV感染毛细支气管炎患儿为研究对象,按随机数表法将其分为观察组和对照组,每组各51例。对照组患儿给予常规对症支持疗法联合布地奈德雾化吸入治疗;观察组患儿在对照组治疗基础上联合孟鲁司特钠治疗。观察并比较两组患儿的临床疗效、喘息缓解所需时间、喘息复发率及治疗前后血清CysLTs、ECP水平。结果治疗后,观察组患儿喘息缓解所需时间显著短于对照组(t=4.635,P <0.001),临床总有效率显著高于对照组(U=4.722,P <0.001),两组患儿血清CysLTs和ECP水平均显著低于治疗前(P_均<0.01),且观察组患儿血清CysLTs和ECP水平均明显低于对照组(P_均<0.01)。治疗12周内,观察组患儿治疗喘息复发率显著低于对照组(χ~2=4.080,P=0.043)。结论孟鲁司特钠治疗小儿RSV感染毛细支气管炎,可显著缩短患儿喘息缓解所需时间,临床疗效显著,且可以降低气道炎性标志物水平和喘息复发率。
Objective To investigate the effect of Montelukast sodium on the treatment of bronchiolitis caused by respiratory syncytial virus （RSV） in children and the effect on serum cysteine leukotxienes （CysLTs） and eosinophil cationic protein （ECP） levels. Method 102 children of RSV-infected bronchiolitis admitted to the Nanjing Hospital of Integrated Traditional Chinese and Western Medicine from September 2015 to August 2017 were selected as the main subjects. They were randomly divided into observation group and control group, 51 children in each group. The children in control group received budesonide inhalation on the basis of routine symptomatic support therapy, and observation group children received Montelukast sodium on the basis of control group. The clinical efficacy, time needed for wheezing remission, the recurrence rate of wheezing and serum CysLTs and ECP levels before and after treatment were observed and compared between the two groups. Result After treatment, the time needed for wheezing remission in observation group was significantly shorter than that of control group （t =4.635, P 〈 0.001）, the total effective rate of observation group was higher than that of control group （U = 4.722, P 〈 0.001）, serum CysLTs and ECP levels in the two groups were lower than those before treatment （Pall 〈 0.01）, and the levels of CysLTs and ECP in observation group were significantly lower than those in control group （Pall 〈 0.01）. Within 12 weeks of treatment, the recurrence rate of wheezing in observation group was significantly lower than that in control group （χ^2 = 4.080, P =0.043）. Conclusion Montelukast sodium in the treatment of children with RSV bronchiolitis can help to shorten the required time of wheezing remission, clinical efficacy is significant, it can reduce the level of airway inflammatory markers and reduce the recurrence rate of wheezing.
作者
夏小兰
马露
崔倪
XIA Xiao-lan;MA Lu;CUI Ni(Department of Pediatrics,Nanjing Integrated Tiaditional Chinese and Western Mdeicine Hospital,Nanjing 210014,China;Wuhan University School of Health Sciences,Wuhan 430070,China)
出处
《中国医学前沿杂志（电子版）》
2018年第11期24-27,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
湖北省卫生计生委创新团队项目(WJ2017M008)
