摘要
目的探讨原发乳腺弥漫大B细胞淋巴瘤(Primary Breast Diffuse Large Cell Lymphoma,PB-DCBCL)的临床特征及预后因素,以提高对原发乳腺弥漫大B细胞淋巴瘤的认识。方法回顾性分析我院2010年1月—2019年8月收治的17例原发乳腺弥漫大B细胞淋巴瘤患者临床资料,所有患者均为女性,5例患者行CHOP方案,3例行R-CHOPE方案,其余9例患者行R-CHOP方案化疗。采用Kaplan-Meier法计算患者累计生存率,组间差异性分析采用Log rank检验。结果17例患者均因发现乳腺肿块就诊,行局部肿块切除或行乳腺根治术,进行Ann Arbor分期,其中:Ⅰ期6例,Ⅱ期9例,Ⅳ期2例;生发中心起源14例,非生发中心起源2例,不能分类1例,PB-DLBCL 5年OS 76%,PFS 70%,高β2微球蛋白及临床分期Ⅳ期患者预后差。结论PB-DLBCL多发于女性,累及单侧乳腺居多,临床表现为局部无痛性包块,临床对化疗敏感,但部分患者易复发,预后与临床分期及β2微球蛋白有关。
Objective To explore the clinical features and the prognostic factors of primary breast diffuse large Bcell lymphoma(PB-DLBCL),so as to improve the understanding of PB-DLBCL.Methods The clinical data of 17 patients with PB-DLBCL treated in our hospital from January 2010 to August 2019 were collected and analyzed retrospectively.All the patients were female,5 patients were treated with CHOP regimen,3 patients were treated with R-CHOPE regimen,and the remaining 9 patients were treated with R-CHOP regimen chemotherapy.Kaplan-Meier method was used to calculate the cumulative survival rate of the patients,and Log rank test was used to analyze the differences between groups.Results All the seventeen patients were treated with local mass resection or radical mastectomy,and underwent Ann Arbor staging,including 6 case in stage Ⅰ,9 case in stage Ⅱ,2 cases in stage Ⅳ;14 cases were germinal center B-cell-like lymphoma,2 cases were non-germinal center B-cell-like lymphoma,and 1 case could not be classified.The 5-year OS and PFS of PB-DLBCL patients were 76% and 70% respectively.β2 microglobulin and clinical stage affected the prognosis of the patients,and the patients with high β2-microglobulin and stage Ⅳ had poor prognosis.Conclusion PB-DLBCL is more common in women,mostly involved in one side.The clinical manifestation is local painless mass,which is sensitive to chemotherapy,but some patients are prone to relapse.The prognosis is related to the clinical stage and β2 microglobulin.
作者
闫冬梅
宋旭光
孙财
桑威
赵猛
YAN Dong-mei;SONG Xu-guang;SUN Cai;SANG Wei;ZHAO Meng(Institute of Hematology,Xuzhou Medical University,Xuzhou 221000,Jiangsu,China)
出处
《中国校医》
2020年第12期887-889,943,共4页
Chinese Journal of School Doctor
基金
江苏省自然科学基金(BK20171181)。
关键词
原发乳腺
弥漫大B细胞淋巴瘤
临床特点
primary breast
diffuse large B-cell lymphoma
clinical feature
