摘要
目的观察低频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗脑卒中后失眠的临床疗效。方法收集2018年12月至2019年12月武汉大学中南医院康复医学科住院的脑卒中失眠患者58例,男35例,女23例,采用随机数字法将患者分为对照组(n=28)和rTMS治疗组(n=30),两组患者均接受常规基础性治疗和康复护理,对照组患者给予口服阿普唑仑片治疗失眠,rTMS治疗组患者接受低频rTMS治疗,疗程均为1个月。比较两组患者治疗前和治疗1个月后匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)评分、神经功能缺损评分(National Institutes of Health Stroke Scale,NIHSS)以及不良反应发生率的差异。结果两组患者治疗前PSQI和NIHSS评分比较无统计学差异(均P>0.05);治疗1个月后,两组患者PSQI和NIHSS评分均较治疗前改善(均P<0.05),且rTMS治疗组PSQI及NIHSS评分改善程度高于对照组(P<0.05)。对照组不良反应发生率高于治疗组(P<0.05)。结论低频rTMS能有效改善脑卒中后失眠患者的睡眠质量,促进患者神经功能的恢复,安全性高,值得临床推广应用。
Objective To observe the clinical efficacy of repetitive Transcranial Magnetic Stimulation(rTMS)for the treatment of insomnia after stroke.Methods Fifty-eight patients with insomnia after stroke were hospitalized in Department of Rehabilitation Medicine,Zhongnan Hospital of Wuhan University from December 2018 to December 2019,including 35 males and 23 females.The patients were randomly divided into a control group(n=28)and an rTMS treatment group(n=30).Both groups received routine basic treatment and rehabilitation nursing.Patients in the control group were given alprazolam tablets for insomnia,while in the rTMS treatment group received low-frequency rTMS.The Pittsburgh Sleep Quality Index(PSQI)and the NIHSS were used to evaluate the sleep quality and neurological deficits of patients before and 1 month after treatment,the incidence of adverse reactions was also recorded in both groups.Results There was no significant difference in the scores of PSQI and NIHSS between the two groups(P>0.05)before treatment;After 1 month of treatment,the scores of PSQI and NIHSS in both groups were improved compared with those before treatment(P<0.05),but the improvement was more significant in the rTMS treatment group than that in the control group(P<0.05),the incidence of adverse reactions in the control group was significantly higher than that in the rTMS treatment group(P<0.05).Conclusions Low-frequency rTMS can effectively improve the sleep quality and promote the recovery of neurological function with high safety in patients with insomnia after stroke,which is worthy of clinical application.
作者
徐丹
田峻
陈晨
陶陶
XU Dan;TIAN Jun;CHEN Chen;TAO Tao(不详;Department of Rehabilitation Medicine,Guizhou Provincial People's Hospital,Guiyang Guizhou 550002,China)
出处
《中国神经免疫学和神经病学杂志》
CAS
北大核心
2021年第1期58-60,66,共4页
Chinese Journal of Neuroimmunology and Neurology
