摘要
目的检测广西某美沙酮维持治疗(methadone maintenance treatment,MMT)门诊丙型肝炎病毒(hepatitis C,HCV)抗体阳性者的HCV病毒载量探讨其相关影响因素。方法对广西南宁市MMT门诊HCV抗体阳性就诊者进行调查,收集一般人口学信息、吸毒及HIV感染情况等,并进行HCV病毒载量、血常规、肝功能等测定。结果共检测257人,其中209人(81.32%)HCV-RNA阳性,48人(18.68%)HIV抗体阳性,139人(54.09%)AST/ALT>1;随着HCV-RNA载量升高,AST和ALT异常比例及HCV/HIV合并感染比例增加(χ^2趋势检验,均P<0.05)。结论MMT门诊中HCV抗体阳性者大多为现症丙型病毒性肝炎(简称丙肝)患者,部分已进展到肝纤维化或肝硬化,且病毒载量与AST、ALT异常及HIV合并感染有关,提示应重视该人群的丙肝防治,并遏制HCV进一步传播。
Objective To detect the HCV-RNA viral load among anti-HCV positive attendants in a methadone maintenance treatment(MMT)clinic in Guangxi,and to explore its associated influencing factors.Methods We surveyed anti-HCV positive attendants in a methadone maintenance treatment(MMT)clinic in Guangxi Province.Their information about general demography,drug addiction and HIV infection status was collected,and laboratory tests including HCV-RNA viral load,blood routine and liver function were conducted.Results A total of 257 anti-HCV positive attendants received the above-mentioned laboratory tests.Among them,209(81.32%)were HCV-RNA-positive,48(18.68%)were HIV positive,and 139(54.09%)had an AST/ALT ratio above 1.Along with the growth of HCV-RNA viral load,the rates of abnormal AST value,abnormal ALT value and HCV/HIV co-infection all increased(Chi-square test for trend test,all P<0.05).Conclusions Most of the anti-HCV positive attendants in the MMT clinic are patients with chronic hepatitis C virus infection,and some of them have already developed into liver fibrosis or cirrhosis.In addition,the viral load is correlated with abnormal AST value,abnormal ALT value,and HIV/HCV co-infection.It is suggested that more attention should be paid to HCV prevention and treatment so as to contain further spread of HCV.
作者
李荣健
潘玲
石珊
韦利葵
蓝光华
庞琳
LI Rong-jian;PAN Ling;SHI Shan;WEI Li-kui;LAN Guang-hua;PANG Lin(Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Nanning,Guangxi 530028,China;National Center for AIDS/STD Control and Prevention,China CDC,Beijing 102206,China;Red Cross Hospital of Nanning City,Nanning,Guangxi 530012,China)
出处
《实用预防医学》
CAS
2021年第1期29-31,共3页
Practical Preventive Medicine
基金
中美艾滋病防治合作项目(5uzGGH001153)。
关键词
美沙酮维持治疗
丙型病毒性肝炎
病毒载量
HIV
肝功能
methadone maintenance treatment
hepatitis C
viral load
human immunodeficiency virus
liver function
