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T细胞耗竭机制的研究进展 被引量:3

Research progress in mechanisms of T cell exhaustion
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摘要 在慢性感染性疾病及肿瘤的进展过程中,持续性的抗原刺激会导致T细胞耗竭。耗竭T细胞的效应功能会在疾病进展过程中逐渐出现障碍直至丧失,从而影响机体对疾病的有效控制。T细胞耗竭的机制以及通过逆转耗竭T细胞来治疗慢性感染性疾病和肿瘤已成为近年的研究热点。本文将对耗竭T细胞的主要特点、耗竭现象的逆转及其与疾病之间的关系进行综述。 T cell exhaustion displays stepwise and progressive losing of immune functions under conditions of antigen-persistence stimulation,which occurs following chronic infections and tumor progression.And the host always cannot control infections and tumors effectively because of T cell exhaustion.Mechanism of T cell exhaustion as well as the treatment of chronic infectious diseases and tumors by reversing exhausted T cells have become a research hotspot in recent years.This article will review the main features of exhausted T cells,the reversal of T cell exhaustion and the relationship between T cell exhaustion and diseases.
作者 刘宁 徐屹 段丁瑜(指导) LIU Ning;XU Yi;DUAN Ding-Yu(State Key Laboratory of Oral Diseases,Department of Periodontology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2021年第1期103-108,共6页 Chinese Journal of Immunology
基金 国家自然科学基金项目(81700984)。
关键词 耗竭T细胞 抑制性受体 细胞因子 慢性感染 T cell exhaustion Inhibitory receptors Cytokines Chronic infections
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  • 1崔晓利,李文侠,李峰,孙惠平,董荣秀.结核病患者外周血中淋巴细胞亚群变化及其临床意义[J].现代检验医学杂志,2007,22(4):69-70. 被引量:5
  • 2Khan N, Gowthaman U, Pahari S, et al. Manipulation of costimulatory molecules by intracellular pathogens: veni, vidi, vicill [J]. PLoS Pathog,2012,8(6) : e1002676. 6. 被引量:1
  • 3Okazaki T, Honjo T. PD-1 and PD-1 ligartds: from discovery to clinical application [ J ]. Int Immuno1,2007,19 (7) :813-824. 被引量:1
  • 4Keir ME, Butte MJ, Freeman GJ, et al. PD-1 and its ligands in tolerance and immunity [ J ] . Annu Rev Immunol, 2008, 26: 677-704. 被引量:1
  • 5Fife BT, Pauken KE. The role of the PD-1 pathway in autoimmunity and peripheral tolerance [ J ]. Ann N Y Aead Sei, 2011,1217:45-59. 被引量:1
  • 6Sznol M, Chen L Antagonist antibodies to PD-I and B7-H1 (PD-L1) in the treatment of advanced human cancer: response [ J]. Clin Cancer Res,2013,19 (19) :5542. 被引量:1
  • 7Figueira EA, de Rezende ML, Torres SA, et al. Inhibitory signals mediated by programmed death-1 are involved with T-cell function in chronic periodontitis [ J ] . J Periodontol, 2009, 80 ( 11 ) : 1833-1844. 被引量:1
  • 8Armitage GC. Development of a classification system for periodontal diseases and conditions [ J ]. Ann Periodontol, 1999,4 (1):1-6. 被引量:1
  • 9盂焕新.牙周病学[M].4版.北京:人民卫生出版社,2013:169-171. 被引量:2
  • 10Fuller MJ, Callendret B, Zhu B, et al. Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1) [J]. Proc Natl Acad Sci U S A,2013,110(37) : 15001-15006. 被引量:1

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