摘要
目的:探讨桔贝合剂联合布地奈德治疗儿童支气管哮喘的临床疗效。方法:选取2018年1月至2020年1月盐城市第三人民医院收治的支气管哮喘患儿116例,依照随机数字表法分为对照组(58例)和观察组(58例)。对照组患儿采用布地奈德治疗,观察组患儿给予桔贝合剂联合布地奈德治疗,两组患儿均连续治疗14 d。治疗后进行临床疗效评价,观察两组患儿的咳嗽、喘息、肺部哮鸣音及肺部湿性啰音等症状缓解时间,治疗前后的第1秒用力呼气容积(FEV 1)、用力肺活量(FVC)、第1秒用力呼气容积占预计值的百分比(FEV 1%)及血清C反应蛋白(CRP)、白细胞介素4(IL-4)和白细胞介素10(IL-10)水平,治疗过程中的不良反应发生情况。结果:观察组患儿的总有效率为96.55%(56/58),明显高于对照组的86.21%(50/58),差异有统计学意义(P<0.05)。观察组患儿症状缓解时间(包括咳嗽、喘息、肺部哮鸣音及肺部湿性啰音等)明显短于对照组,差异均有统计学意义(P<0.05)。与治疗前比较,两组患儿FEV 1、FVC及FEV 1%水平于治疗后明显升高,且观察组患儿上述指标明显较对照组更高,差异均有统计学意义(P<0.05)。与治疗前比较,两组患儿血清CRP、IL-4水平于治疗后明显降低,血清IL-10水平于治疗后明显升高;与对照组比较,观察组患儿治疗后的血清CRP、IL-4水平明显更低,血清IL-10水平明显更高,差异均有统计学意义(P<0.05)。观察组、对照组患儿治疗期间不良反应发生率分别为10.34%(6/58)、6.90%(4/58),差异无统计学意义(P>0.05)。结论:桔贝合剂联合布地奈德治疗儿童支气管哮喘的临床疗效显著,能够明显缩短临床症状缓解时间,改善肺功能,减轻炎症反应,且安全性较好。
OBJECTIVE:To probe into the clinical efficacy of Jubei mixture combined with budesonide in the treatment of bronchial asthma in children.METHODS:Totally 116 children with bronchial asthma admitted into the Third People’s Hospital of Yancheng from Jan.2018 to Jan.2020 were selected and divided into control group and observation group via random number table,with 58 cases in each group.The control group was treated with budesonide,while the observation group was given Jubei mixture combined with budesonide,both groups were continuously treated for 14 days.Evaluation on clinical efficacy was conducted after treatment,remission times of cough,gasp,lung wheezing and lung moist rales,forced expiratory volume in one second(FEV 1),forced vital capacity(FVC),the proportion of FEV 1 accounted for its predicted value(FEV 1%),serum C-reactive protein(CRP),interleukin 4(IL-4),interleukin 10(IL-10)levels before and after treatment,and incidence of adverse drug reactions of the two groups during treatment were observed.RESULTS:The total effective rate of observation group was 96.55%(56/58),which was significantly higher than that of the control group(86.21%,50/58),with statistically significant difference(P<0.05).The remission times of cough,gasp,lung wheezing and lung moist rales of observation group were significantly shorter than those of the control group,with statistically significant differences(P<0.05).Compared with before treatment,the FEV 1,FVC and FEV 1%levels of both groups had been significantly increased,and those of the observation group were significantly higher than the control group,with statistically significant differences(P<0.05).Compared with before treatment,after treatment,the serum CRP and IL-4 levels of both groups had been significantly decreased,while the serum IL-10 levels were significantly increased;the serum CRP and IL-4 levels of observation group were significantly lower than those of the control group,while the serum IL-10 level of observation group was significantly higher than those of the
作者
周力
蔡旭龙
徐巧岚
周陈荣
ZHOU Li;Cai Xulong;XU Qiaolan;ZHOU Chenrong(Dept.of Pediatrics,the Third People’s Hospital of Yancheng,Jiangsu Yancheng 224001,China)
出处
《中国医院用药评价与分析》
2020年第12期1445-1448,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
江苏省妇幼健康科研项目(No.FY2017043)。
