摘要
无长突细胞(AC)是视网膜中亚型最丰富的抑制性中间神经元,可分泌多种神经递质,维持视网膜细胞的生长、发育,调控视觉电信号的转导、视敏度、昼夜节律等正常视功能。目前,不同AC在视网膜发育过程中的机制仍未完全可知,但内源性调控因子被认为是AC分化、成熟的关键,也是引起视功能障碍的主要原因。除参与视网膜的正常生理功能外,AC还与近视、孔源性视网膜脱离、视网膜色素变性、青光眼等眼科疾病的发生、发展密切相关。因此,全面了解AC的分化、调控及功能,对进一步探索眼科疾病的病理过程具有重要意义,并可为眼科疾病的早期诊断及治疗提供新思路。
Amacrine cell(AC)is the most abundant subtype of inhibitory intermediate neurons in the retina,which can maintain the growth and development of retinal cells,regulate the normal visual functions such as the transmission of visual signals,visual acuity and circadian rhythm through secreting a variety of neurotransmitters.Although the mechanism of different ACs in the retina development is still not fully understood,so far,endogenous regulatory factors have been considered to be the key to the differentiation and maturation of AC,and also the main cause of visual dysfunction.In addition to partici-pating in the normal physiological functions of the retina,AC is also closely related to the occurrence and development of ophthalmic diseases such as myopia,rhegmatogenous retinal detachment,retinitis pigmentosa,and glaucoma.Therefore,a comprehensive understanding of the differentiation,regulation and function of AC is of great significance for further exploration of the pathological process of the diseases,and can provide new ideas for the early diagnosis and treatment of ocular diseases.
作者
吴梦娟
沈吟
WU Mengjuan;SHEN Yin(Eye Center,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《医学综述》
2021年第1期36-41,47,共7页
Medical Recapitulate
基金
国家重点研发计划(2017YFE0103400)。
关键词
无长突细胞
视网膜
内源性调控因子
细胞分化
眼科疾病
Amacrine cells
Retina
Endogenous regulatory factors
Cell differentiation
Ocular diseases
