摘要
目的观察急性等容性血液稀释(ANH)在稀有血型患者恶性肿瘤切除术中应用的安全性。方法行恶性肿瘤切除术的稀有血型患者41例;其中,Rh阴性患者39例,类孟买血型患者1例,Cis-AB血型患者1例。41例患者实施了ANH,检测术前与术后1 d血红蛋白、红细胞压积(Hct)、血小板、血清肌酐和血尿素氮水平,记录术后住院期间并发症发生情况。结果所有患者ANH采血过程顺利,无低血压或心律失常等不良反应发生。自体血保存完好,无一例出现溶血或血凝块。自体血回输后,无溶血反应发生。术后1 d的Hct低于术前[(37.7±4.4)%vs.(40.5±4.2)%](P<0.01)。患者均无脑梗死或心肌梗死等严重缺血性事件以及术后急性肾功能不全发生。结论ANH有助于保障行恶性肿瘤切除术的稀有血型患者围手术期安全,是一项值得推广的自体输血技术。
Objective To observe the safety of acute normovolemic hemodilution(ANH)in rare blood group patients undergoing malignant tumor resection.Methods ANH was performed in forty-one rare blood group patients underwent malignant tumor operation,of whom 39 cases were Rh negative,one case was with Mumbai-like blood type,and one case was with Cis-AB blood type.The levels of hemoglobin,hematocrit(Hct),platelets,serum creatinine and blood urea nitrogen were determined.The incidence of complications during postoperative hospitalization was recorded.ResultsANH blood collection process was smooth without hypotension,arrhythmia and other adverse reactions in all patients.Autologous blood was well preserved and no hemolysis or clot occurred.There was no hemolytic reaction after autologous blood transfusion.Hct was lower one day after operation than that before[(37.7±4.4)%vs.(40.5±4.2)%](P<0.01).No serious ischemic events such as cerebral infarction or myocardial infarction and acute renal insufficiency occurred after operation.Conclusion ANH is helpful to ensure the perioperative safety of rare blood group patients undergoing malignant tumor resection,and is a worthy autologous blood transfusion technique.
作者
倪燕
周小玉
李娜娜
陈大鹏
丁夏皓
徐智杰
桂波
NI Yan;ZHOU Xiaoyu;LI Nana(Department of Anesthesia and Perioperative Medicine,First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,CHINA)
出处
《江苏医药》
CAS
2020年第12期1219-1221,共3页
Jiangsu Medical Journal
基金
国家自然科学基金(81801061)。
关键词
急性等容性血液稀释
稀有血型
恶性肿瘤
Acute normovolemic hemodilution
Rare blood group
Malignant tumor
