摘要
NLRP3炎性小体是一种结构复杂、调控机制尚不明确的多蛋白复合体,它的过度活化涉及多个系统疾病的病理生理过程。脑缺血(CI)作为发病率最高的脑血管疾病,由于对其溶栓治疗的应用受限,因而开发CI后神经保护药物尤为重要。寻求有效的药物靶点可能为脑缺血再灌注损伤(CIRI)提供新的治疗思路。
NLRP3 inflammasome is a polyprotein complex with complicated structure and unknown regulatory mechanism.Excessive activation of NLRP3 inflammasome is believed to be related to pathophysiological processes with multiple systemic diseases.Cerebral ischemia is the cerebrovascular disease with the highest incidence.Due to the limited application of thrombolytic therapy,it is particularly important to develop neuroprotective drugs after cerebral ischemia.Identification effective drug targets may provide new approaches in the treatment of cerebral ischemia-reperfusion injury(CIRI).
作者
郭艳芹
殷博凯
张娟
何治
GUO Yan-qin;YIN Bo-kai;ZHANG Juan;HE Zhi(Medical College of Three Gorges University,Yichang 443002,China)
出处
《基础医学与临床》
2021年第1期120-124,共5页
Basic and Clinical Medicine
基金
天然产物研究与利用湖北省重点实验室开放基金(NPRD-2018001)
2020年三峡大学研究生学位论文培优基金(2020SSPY106)。
关键词
脑缺血再灌注
NLRP3炎性小体
活化
负向调控
cerebral ischemia-reperfusion
NLRP3 inflammasome
activation
negative regulation
