摘要
目的:观察火针联合舒肤散熏洗治疗银屑病的疗效。方法:选取200例银屑病患者为研究对象,采用信封法随机分为观察组和对照组各100例。对照组给予火针治疗,观察组在此基础上联合舒肤散熏洗治疗。比较2组治疗前后症状积分、银屑病皮损面积和严重性指数(PASI)评分、血清学指标及炎症因子水平,比较2组临床疗效、不良反应发生率及复发率。结果:观察组总有效率为96.00%,高于对照组的84.00%,差异有统计学意义(P<0.05)。治疗后,2组红斑、鳞屑、瘙痒、PASI评分均降低(P<0.05),观察组红斑、鳞屑、瘙痒、PASI评分均低于对照组(P<0.05);2组血管内皮生长因子(VEGF)、丙二醛(MDA)、脂质过氧化物(LPO)水平均降低(P<0.05),观察组VEGF、MDA、LPO水平均低于对照组(P<0.05)。2组白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)、肿瘤坏死因子-α(TNF-α)水平均降低(P<0.05),观察组IL-6、IL-8、TNF-α水平均低于对照组(P<0.05)。不良反应发生率观察组为5.00%(5/100),对照组为8.00%(8/100),2组比较,差异无统计学意义(P>0.05)。随访6个月,观察组复发率为2.08%(2/96),对照组复发率为11.90%(10/84),2组比较,差异有统计学意义(P<0.05)。结论:火针联合舒肤散熏洗治疗银屑病疗效确切,可显著改善患者临床症状,减轻机体炎症反应,降低银屑病复发率,安全有效。
Objective: To observe the curative effect of fire needle combined with fumigation and washing with Shufu powder for psoriasis. Methods:A total of 200 cases of patients with psoriasis were selected as the study subjects and divided into the observation group and the control group according to the envelope method,100 cases in each group. The control group was treated with fire needle, and the observation group was additionally treated with fumigation and washing with Shufu powder based on the treatment of the control group. Before and after treatment,the symptom scores,the area of psoriatic lesions,the scores of Psoriasis Area and Severity Index(PASI),serum indexes and the levels of inflammatory factors in the two groups were compared. The curative effect,incidences of adverse reactions and the recurrence in the two groups were compared. Results: The total effective rate of treatment was 96.00% in the observation group, higher than that of84.00% in the control group, the difference being significant(P<0.05). After treatment, the scores of erythema, scales,pruritus and PASI in the two groups were decreased(P<0.05), and the above scores in the observation group were lower than those in the control group(P<0.05);the levels of vascular endothelial growth factor(VEGF),malondialdehyde(MDA) and lipid peroxide(LPO) in the two groups were decreased(P<0.05),and the above levels in the observation group were all lower than those in the control group(P<0.05). The levels of interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α) in the two groups were decreased(P<0.05), the levels of IL-6, IL-8 and TNF-α in the observation group were lower than those in the control group(P<0.05). The incidence of adverse reactions was 5.00%(5/100) in the observation group and 8.00%(8/100) in the control group,there being no significance in the difference(P>0.05). After six-month follow-up,the recurrence rate was 2.08%(2/96) in the observation group and 11.90%(10/84) in the control group,the difference being significant(P<0.0
作者
张建强
荣姗姗
ZHANG Jianqiang;RONG Shanshan
出处
《新中医》
CAS
2020年第23期115-118,共4页
New Chinese Medicine
关键词
银屑病
火针
中药熏洗
银屑病皮损面积和严重性指数
炎症因子
脂质过氧化物
丙二醛
血管内皮生长因子
Psoriasis
Fire needle
Chinese herbal fumigation and washing
Psoriasis Area and Severity Index
Inflammatory factors
Lipid peroxide
Malondialdehyde
Vascular endothelial growth factor
