摘要
Ras相关区域家族1A(RASSF1A)基因为RASSF家族成员,其以三磷酸鸟苷依赖性方式结合Ras继而诱导由Ras介导的凋亡。RASSF1A基因编码的蛋白类似于Ras效应蛋白,可与DNA修复蛋白XPA相互作用,还可抑制细胞周期蛋白D1的积累,从而诱导细胞周期停滞。RASSF1A基因缺失或表达异常与多种恶性肿瘤的发病机理有关,表明其具有肿瘤抑制功能。已在至少37种肿瘤中发现了RASSF1A基因甲基化,RASSF1A基因可能是目前人类癌症中描述最频繁的甲基化基因。介绍了RASSF1A基因在不同恶性肿瘤中的异常甲基化,并综述了近年来其在呼吸系统、消化系统、生殖泌尿系统、神经系统恶性肿瘤中的相关作用及机制的研究进展,以期为恶性肿瘤的早期诊断、个体分子靶向治疗及预后评估提供重要的指导依据。
Ras-associated domain family 1A(RASSF1A)genes are members of the RASSF family,which bind to Ras in a guanosine triphosphate(GTP)-dependent manner and then induce Ras-mediated apoptosis.The protein encoded by the RASSF1A gene is similar to the Ras effector protein,which can interact with DNA repair protein XPA,and can also inhibit the accumulation of cyclin D1,thereby inducing cell cycle arrest.The deletion or abnormal expression of RASSF1A gene is related to the pathogenesis of various malignant tumors,indicating that it has tumor suppressor function.RASSF1A gene methylation has been found in at least 37 tumors,and RASSF1A gene may be the most frequently described methylated gene in human cancers.In this paper,the abnormal methylation of RASSF1A gene in different malignant tumors was introduced,and the research progress of its related effects and mechanisms in malignant tumors of the respiratory system,digestive system,genitourinary system,and nervous system in recent years was reviewed,with a view to malignant tumors early diagnosis,individual molecular targeted therapy and prognostic evaluation provide important guidance.
作者
张杨秋蓉
冯静云
张婕
杨静雅
罗金金
林堉娇
盛苗苗
Zhangyang Qiurong;Feng Jingyun;Zhang Jie;Yang Jingya;Luo Jinjin;Lin Yujiao;Sheng Miaomiao(Medical School,Kunming University of Science and Technology,Kunming 650500,China)
出处
《国际生物医学工程杂志》
CAS
2020年第5期418-424,共7页
International Journal of Biomedical Engineering
基金
国家级大学生创新创业训练计划项目(201810674015)
云南省卫生科技计划项目(2016N2228)。
