摘要
目的:考察免疫性不孕患者全血微量元素铜(Cu)、锌(Zn)、硒(Se)水平和血清炎性因子白细胞介素(Interleukin,IL)-6、IL-8、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)水平,明确微量元素、炎性因子与免疫性不孕的关系。方法:回顾性选择40例免疫性不孕患者作为研究组,另以同期40名健康者作为对照。对两组全血微量元素Cu、Zn、Se进行检测,以酶联免疫法试剂盒检测血清IL-6、IL-8以及TNF-α,并对Cu、Zn、Se水平和IL-6、IL-8、TNF-α与免疫性不孕的相关性进行分析。结果:研究组的全血Cu水平显著高于对照组,而Zn、Se水平显著低于对照组(P<0.05),即免疫性不孕患者全血微量元素Cu、Zn和Se水平异常,其中Cu异常增高,而Zn和Se异常降低;研究组患者的IL-6、IL-8和TNF-α均显著高于对照组健康女性(P<0.05),即免疫性不孕患者血清存在炎性因子的异常增高;全血微量元素Cu、Zn、Se和血清炎性因子IL-6、IL-8、TNF-α均与免疫性不孕密切相关(P<0.05)。结论:免疫性不孕患者全血微量元素Cu和Zn水平异常,血清炎性因子水平异常,微量元素和炎性因均与免疫性不孕密切相关。
Objective: Investigate the levels of trace elements Cu, Zn, Se in whole blood and the levels of inflammatory factors IL-6, IL-8 and TNF-α in serum of patients with immune infertility, inflammatory factors and immune infertility. Methods: Forty patients with immune infertility were used as the study group, and 40 healthy persons were used as controls. The trace elements Cu, Zn and Se in whole blood in the two groups were detected by a medical trace element analyzer, and the serum IL-6, IL-8 and TNF-α were detected by the enzyme-linked immunoassay kit, and the Cu, Zn and Se in whole blood level and correlation between IL-6, IL-8, TNF-α and immune infertility were analyzed. Results: The whole blood Cu level in the study group was significantly higher than that in the control group,while the whole blood Zn and Se levels were significantly lower than the control group(P<0.05), the levels of whole blood trace elements Cu, Zn and Se in patients with immune infertility are abnormal, of which Cu abnormally increases and Zn and Se abnormally decreases.The IL-6, IL-8 and TNF-α in the study group were significantly higher than those in the control group(P<0.05), there is an abnormal increase in inflammatory factors in serum of patients with immune infertility. The whole blood trace elements Cu, Zn and inflammatory factors IL-6, IL-8, and TNF-α in vaginal secretions are all closely related to immune infertility(P<0.05). Conclusion: The levels of whole blood trace elements Cu, Zn and Se in patients with immune infertility are abnormal, and the levels of inflammatory factors in serum are abnormal.
作者
贾秦亮
白重阳
段美婷
薛艳
兰良子
谢云
JIA Qin-liang;BAI Chong-yang;DUAN Mei-ting;XUE Yan;LAN Liang-zi;XIE Yun(Department of Laboratory Medicine,Northwest Women's and Children's Hospital,Xi'an,Shaanxi,710061,China;Department of Laboratory Medicine,Tangdu Hospital,Second Affiliated Hospital of PLA Military Medical University,Xi'an,Shaanxi,710038,China)
出处
《现代生物医学进展》
CAS
2020年第21期4117-4120,4181,共5页
Progress in Modern Biomedicine
基金
陕西省自然科学基础研究计划项目(2016JQ8058)。
关键词
免疫性不孕
相关性
微量元素
炎性因子
Immune infertility
Correlation
Trace elements
Inflammatory factors
