摘要
目的:近年来长链非编码RNA(lnc RNA)的研究快速兴起,由于其作用机制多样,且生物学功能更加强大,已成为表观遗传学领域一个新的研究热点。越来越多的研究报道lnc RNA通过调控靶基因的表达,进而参与女性生殖疾病的发生与发展。其中lnc RNA与流产相关疾病机制的关系逐渐受到学者的重视。笔者系统性地回顾了近10年国内外发表的相关文献,从lnc RNA对胚胎发育能力、胎盘发育、子宫内膜容受性、胚胎-母源交互作用的调控等方面,考究其对复发性流产与反复着床失败的影响,为进一步的表观遗传学研究提供方向。
Currently,the study on long non coding RNA(lnc RNA)has been rising rapidly.It has become a hotspot in epigenetics due to its diverse mechanisms and powerful biological functions.More and more studies have reported that lnc RNA has been involved in some female reproductive diseases by regulating the expression of target genes.Among them,the relationship between the lnc RNA and miscarriage related diseases has been paid more attention by scholars.The authors systematically review the relevant literature published at home and abroad in recent 10 years,and investigate the effect of lnc RNA on the regulation of embryonic,placenta development,endometrial receptivity,and embryo and maternal interaction on the recurrent miscarriage or repeated implantation failure of the fertilized egg,so as to offer a new direction for further research of epigenetics.
作者
赵小萱
冯晓玲
陈璐
王玮
ZHAO Xiaoxuan;FENG Xiaoling;CHEN Lu;WANG Wei(University of Traditional Chinese Medicine, Harbin, Heilongjiang Province,150040;The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine)
出处
《中国计划生育学杂志》
2020年第11期1929-1934,共6页
Chinese Journal of Family Planning
基金
国家自然科学基金(81574014,81373673)。
关键词
长链非编码RNA
复发性流产
反复着床失败
研究进展
综述
Long non coding RNA
Recurrent abortion
Repeated implantation failure of the fertilized egg
Research progress
