摘要
妊娠是人类发展过程中巧妙而精密的过程,在妊娠过程中人类面临着许多挑战,复发性流产(RSA)是一种常见的不良妊娠结局,影响约5%的育龄期女性。微小RNA(miRNA)是一种非编码RNA,可通过靶向信使RNA(mRNA)发挥其生物学功能。许多研究已经发现,miRNA通过参与血管生成、细胞凋亡、免疫反应等多种生物学事件参与RSA进程。RSA与miRNA的研究既有助于探寻RSA病因多样化背后的机制,也为RSA的治疗提供了更多新思路。
Pregnancy is an ingenious and precise process in the procedure of human development.During pregnancy,human beings are faced with many challenges,recurrent spontaneous abortion(RSA)is a common adverse pregnancy outcome.Micro ribonucleic acid(miRNA)is a kind of non-coding RNA,which can play its biological function by targeting messenger ribonucleic acid(mRNA).Many studies have found that miRNA participates in RSA through angiogenesis,apoptosis,immune response and other events.The study of RSA and miRNA can not only help to explore the mechanism behind the diversification of RSA etiology,but also provide more new ideas for the treatment of RSA.
作者
涂许许
赵小萱(综述)
冯晓玲(审校)
TU Xuxu;ZHAO Xiaoxuan;FENG Xiaoling(Graduate School,Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China;the Second Department of Gynaecology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China)
出处
《国际检验医学杂志》
CAS
2021年第22期2799-2803,共5页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目(81973894)。
关键词
复发性流产
微小RNA
信使RNA
recurrent spontaneous abortion
micro ribonucleic acid
messenger ribonucleic acid
