摘要
当肿瘤细胞长期暴露于化疗药物时,细胞表面会过度表达P-糖蛋白。P-糖蛋白过表达可以将大量化疗药物排出细胞外,使细胞内药物浓度显著降低,导致肿瘤细胞多药耐药的产生。P-糖蛋白的表达与核因子κB、丝裂原活化蛋白激酶、磷脂酰肌醇3-激酶/蛋白激酶B等信号通路密切相关。本文就影响P-糖蛋白的相关信号通路及产生肿瘤多药耐药的机制进行综述。
When tumor cells are exposed to chemotherapy drugs for a long time,the surface of tumor cells will over express P-glycoprotein.Overexpression of P-glycoprotein can lead to the efflux of a large number of intracellular chemotherapeutic drugs,which significantly reduces the intracellular drug concentration and leads to drug resistance in tumor cells.The expression of P-glycoproteinis closely related to mitogen-activated protein kinase,nuclear factor κB,phosphatidylinositol-3-kinase/protein kinase B and other signaling pathways.In this paper,we reviewed the related signaling pathways affecting P-glycoprotein and the mechanism of multidrug resistance.
作者
刘亨晶
魏敏
孙瑾瑜
于晓辉
张久聪
LIU Heng-Jing;WEI Min;SUN Jin-Yu;YU Xiao-Hui;ZHANG Jiu-Cong(Department of Gastroenterology,940 Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050;Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)
出处
《生物技术通讯》
CAS
2020年第5期580-584,共5页
Letters in Biotechnology
基金
国家自然科学基金(81500454)
西北民族大学中央高校基本科研业务费(31920200014)
军队医药卫生科研基金(CLZ15JA02)。
关键词
P-糖蛋白
肿瘤多药耐药
信号通路
机制
进展
P-glycoprotein
multidrug resistance of tumor
signal pathway
mechanism
advance
