摘要
目的分析微炎性因子在血液透析治疗慢性肾衰竭(CRF)中的表达及与预后的相关性。方法收集2017年4月—2018年6月行血液透析治疗的76例CRF(CRF组)临床资料,另选取同期非血液透析治疗良性疾病患者(对照组)67例,分析不同人群微炎性因子水平,随访了解血液透析治疗CRF患者1年后生存情况。根据超敏C反应蛋白(hs-CRP)水平分为hs-CRP升高组32例和hs-CRP正常组44例,观察不同水平hs-CRP的CRF患者心脏功能异常和心血管事件发生率。结果CRF组C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平高于对照组(P<0.01)。hs-CRP升高组心脏功能异常和心血管事件发生率高于hs-CRP正常组(P<0.01)。对76例随访1年后,存活率为59.21%,病死率为40.79%。年龄>60岁、透析时间长、CRP、IL-6、TNF-α水平过高均为导致血液透析CRF患者死亡的独立危险因素(P<0.05,P<0.01)。结论微炎性因子在经血液透析治疗CRF患者中高表达,且CRP、IL-6和TNF-α水平高为导致血液透析CRF患者死亡的独立危险因素,提示在临床上须密切关注患者微炎性因子水平,早期干预对改善患者预后意义重大。
Objective To analyze the expression of micro-inflammatory factors in patients with chronic renal failure(CRF)undergoing hemodialysis and its correlation with prognosis.Methods The clinical data of 76 CRF patients(CRF group)undergoing hemodialysis from April 2017 to June 2018 were collected,and 67 patients with benign disease(control group)who did not undergo hemodialysis during the same period were selected.The levels of micro-inflammatory factors in different people were analyzed,and they were followed up to understand the survival of CRF patients at 1 year after hemodialysis treatment.According to the level of hs-CRP,they were divided into increased hs-CRP group(n=32)and normal hs-CRP group(n=44).In addition,the incidence of cardiac dysfunction and cardiovascular events of CRF patients with different levels of hs-CRP was calculated.Results The levels of CRP,IL-6 and TNF-α in the CRF group were significantly higher than those in the control group(P<0.01).The incidence of cardiac dysfunction and cardiovascular events in the increased hs-CRP group was significantly higher than that in the normal hs-CRP group(P<0.01).After 1-year follow-up in 76 patients,the survival rate was 59.21%,and the mortality rate was 40.79%.Age>60 years,longer duration of hemodialysis,and high levels of CRP,IL-6 and TNF-αwere all independent risk factors for death of CRF patients undergoing hemodialysis(P<0.05,P<0.01).Conclusion Micro-inflammatory factors are highly expressed in CRF patients undergoing hemodialysis,and high levels of CRP,IL-6 and TNF-αare independent risk factors for death of patients with CRF undergoing hemodialysis,suggesting that the attention should be closely paid to the level of micro-inflammatory factors of patients in clinical practice,and early intervention can be of great significance in improving the prognosis of patients.
作者
陈昕
何堤
鲁乃宏
邓莹
CHEN Xin;HE Di;LU Nai-hong;DENG Ying(Department of Nephrology,Hanzhong Central Hospital,Hanzhong,Shaanxi 732000,China)
出处
《解放军医药杂志》
CAS
2020年第12期86-89,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
陕西省卫生厅科研基金项目(2016J392741)。
