摘要
慢性活动性EB病毒感染(chronic active Epstein-Barr virus,CAEBV)属于EBV阳性T细胞或NK细胞增生性疾病,该病起病隐匿,临床表现多样,病程进展快,预后不佳。该文主要从EBV如何感染T/NK细胞、宿主遗传背景、病毒自身因素及细胞因子通路四个方面,对目前CAEBV发病机制的研究进展进行综述。
Chronic active Epstein-Barr virus(CAEBV)infection belongs to EBV positive T cell or NK cell lymphoproliferative diseases,which has an insidious onset,diverse clinical manifestations,rapid progression and poor prognosis.This article mainly reviews the research progress on the pathogenesis of CAEBV from four aspects:how EBV infects T/NK cells,host genetic background,virus factors and cytokine pathway.
作者
魏昂(综述)
王天有
刘炜(审校)
Wei Ang;Wang Tianyou;Liu Wei(National Center for Children's Health,Hematology Oncology Center,Beijing Children's Hospital,Capital Medical University,Beijing 100045,China;Henan Children1 s Hospital,Children's Hospital Affiliated to Zhengzhou University,Hematology Oncology Center,Zhengzhou Children's Hospital,Zhengzhou 450018,China)
出处
《国际儿科学杂志》
2020年第11期755-758,共4页
International Journal of Pediatrics
基金
国家科技重大专项(2017ZX09304029004)
国家自然科学基金(81700186)
河南省科技发展计划项目(122102310499)。
