摘要
目的观察A型肉毒毒素联合普瑞巴林治疗原发性三叉神经痛的疗效及对血清降钙素基因相关肽(CGRP)和5-羟色胺(5-HT)水平的影响。方法选择2017年6月-2019年6月在广东省湛江市第四人民医院内一科就诊的原发性三叉神经痛患者104例,参照随机数字表法分为观察组和对照组,每组52例。对照组给予普瑞巴林胶囊治疗,观察组在对照组治疗基础上给予A型肉毒毒素治疗。比较2组临床疗效、治疗前后生存质量评分、视觉模拟评分法(VAS)疼痛评分、综合症状评分、血清CGRP和5-HT水平。结果观察组总有效率为94.23%,高于对照组的78.85%(χ^2=5.199,P=0.023);治疗后,2组生存质量评分、VAS疼痛评分和综合症状评分均低于治疗前(P <0.01),且观察组低于对照组(P <0.01);治疗后,2组血清CGRP水平均低于治疗前(P <0.01),5-HT水平均高于治疗前(P <0.01),且观察组变化幅度大于对照组(P <0.01)。结论 A型肉毒毒素联合普瑞巴林治疗原发性三叉神经痛的疗效较好,可改善患者临床症状,提高生活质量,且可调节血清CGRP和5-HT水平,值得临床推广应用。
Objective To observe the efficacy of botulinum toxin type A combined with pregabalin in the treatment of primary trigeminal neuralgia and the effect on serum calcitonin gene-related peptide( CGRP) and serotonin( 5-HT) levels.Methods 104 patients with primary trigeminal neuralgia who were treated in the Department of Internal Medicine,the Fourth People’s Hospital of Zhanjiang City,Guangdong Province from June 2017 to June 2019 were selected,and they were divided into observation group and control group according to the random number table method,52 cases in each group. The control group was treated with pregabalin capsules,the observation group was treated with botulinum toxin type A on the basis of the control group. The clinical efficacy,quality of life score before and after treatment,visual analogue scale( VAS) pain score,syndrome score,serum CGRP and 5-HT levels were compared between the two groups. Results The total effective rate of the observation group( 94. 23%) was higher than that of the control group( 78. 85%)( χ^2= 5. 199,P = 0. 023);After treatment,the quality of life scores,VAS pain scores and syndrome scores of the two groups were lower than before treatment( P < 0. 01),and the observation group was lower than the control group( P < 0. 01);After treatment,the serum CGRP levels in the two groups were lower than before treatment( P < 0. 01),and the 5-HT levels were higher than before treatment( P < 0. 01),and the observation group changed more than the control group( P < 0. 01). Conclusion A combination of botulinum toxin and pregabalin is effective in the treatment of primary trigeminal neuralgia,it can improve the clinical symptoms of patients,improve the quality of life,and can adjust serum CGRP and 5-HT levels,worthy of clinical application.
作者
华健灿
庞兆辉
陈志和
叶成林
梁焕
李健伟
HUA Jiancan;PANG Zhaohui;CHEN Zhihe(Department of Internal Medicine,The Fourth People's Hospital of Zhanjiang,Guangdong Province,Zhanjiang 524008,China)
出处
《临床合理用药杂志》
2020年第31期16-19,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
三叉神经痛
A型肉毒毒素
普瑞巴林
降钙素基因相关肽
5-羟色胺
Primary trigeminal neuralgia
Botulinum toxin A type
Pregabalin
Calcitonin generelated peptide
5-hydroxytryptamine
