摘要
目的探讨男性人群糖尿病与单纯性肾囊肿的关系。方法采用巢式病例对照研究方法,以金昌队列随访男性人群中所有新发单纯性肾囊肿且未患有相关肾病以及各研究因素资料完整的病例为病例组,共627例,以随访男性人群未患单纯性肾囊肿且未患有相关肾病以及各资料完整的人群按照病例组基线年龄进行1∶2频数匹配后共纳入对照1254例;应用多因素非条件Logistic回归模型分析糖尿病与单纯性肾囊肿的关系,采用限制三次样条法分析空腹血糖与单纯性肾囊肿的剂量反应关系。结果病例组三酰甘油和高密度脂蛋白胆固醇水平低于对照组(P<0.05),体重指数、收缩压、舒张压、空腹血糖和血尿酸水平均高于对照组(P<0.05)。多因素非条件Logistic回归分析结果显示,在调整了文化程度、体重指数、血尿酸、高血压之后,糖尿病的OR[95%CI]为1.604[1.095,2.349],空腹血糖浓度为5.0~5.9、6.0~6.9、≥7.0mmol/L时,相对于空腹血糖浓度<5.0 mmol/L时,单纯性肾囊肿的OR[95%CI]分别为1.311[1.041,1.651]、1.345[0.939,1.926]、1.676[1.158,2.426],随着空腹血糖水平的增加,单纯性肾囊肿的发病风险呈上升趋势(P趋势=0.004)。限制三次样条法分析结果显示,男性人群空腹血糖水平与单纯性肾囊肿发病风险之间呈非线性剂量反应关系(P整体<0.0001,P非线性=0.0013)。结论糖尿病是男性人群单纯性肾囊肿的危险因素,空腹血糖水平越高,单纯性肾囊肿的发病风险越大。
Objective To study the relationship between diabetes mellitus and simple renal cyst in male population.Methods A nested case-control study was carried out among a male population of Jinchang Cohort,including 627 cases,all new cases of simple renal cyst with no related kidney disease,with their complete information included and 1254 used as controls without simple renal cysts and related kidney disease during the follow-up period.In addition,the cases and controls(1∶2)were matched by a baseline.A multivariate unconditional Logistic regression model was used to analyze the relationship between diabetes and simple renal cyst.A restricted cubic spline model was used to analyze the dose-response association of diabetes mellitus with simple renal cyst.Results The level of triglyceride and high density lipoprotein-cholesterol in the case group was significantly lower than that in the control group,and the level of body mass index,systolic pressure,diastolic pressure,fasting blood sugar and uric acid was in a reversed manner(P<0.05).After adjusting for education,body mass index,triglyceride,high density lipoprotein-cholesterol,serum uric acid and hypertension,the multivariate conditional logistic regression analysis demonstrated that the OR and 95%CI of diabetes mellitus was 1.604[1.095,2.349],compared to fasting blood sugar concentration less than 5.0 mmol/L,when the fasting blood sugar concentration was 5.0~5.9,6.0~6.9 and≥7.0 mmol/L,the odds ratio of simple renal cysts was 1.311[1.041,1.651],1.345[0.939,1.926]and 1.676[1.158,2.426],respectively.The risk of simple renal cyst increased with the increase of the fasting plasma glucose level(Ptrend=0.004).The restricted cubic spline model showed that there was a positive non-linear dose-response association between diabetes mellitus and the risk of simple renal cyst(Poverall<0.0001 and Pnonlinearity=0.0013).Conclusion Diabetes mellitus was a risk factor of simple renal cysts,and this risk would increase with fasting blood sugar.
作者
张亚群
黄文雅
尚婷婷
王潇
黄佩瑶
周静
柳念
丁杰萍
张昉
白亚娜
Zhang Ya-qun;Huang Wen-ya;Shang Ting-ting;Wang Xiao;Huang Pei-yao;Zhou Jing;Liu Nian;Ding Jie-ping;Zhang Fang;Bai Ya-na(Gansu Academy of Eco-environmental Science,Lanzhou 730000,China;School of Public Health,Lanzhou University,Lanzhou 730000,China)
出处
《兰州大学学报（医学版）》
CAS
2020年第6期22-26,共5页
Journal of Lanzhou University（Medical Sciences）
基金
兰州大学“一带一路”专项(2018ldbrzd008)。
关键词
糖尿病
单纯性肾囊肿
相关性
巢式病例对照研究
剂量反应关系
diabetes mellitus
simple renal cyst
relevance
nested case-control study
dose-response relationship
