摘要
目的：分析国人主动脉夹层（AD）发病危险因素的流行病学特征。方法回顾性分析2011年1月1日至2012年12月31日国内15家大型心脏中心的1015例AD患者资料。AD患者为病例组。选取同期在该院住院并排除AD的920例患者为对照组。收集患者年龄、性别、体质指数（BMI）、白塞氏病、高血压、血脂、动脉粥样硬化等方面的资料。结果高血压、马凡综合征、白塞氏病、吸烟、饮酒、单纯性肾囊肿、主动脉二瓣化畸形、动脉粥样硬化、FFA、UA是AD发病的独立危险因素。高血压OR值为9.068，提示高血压与AD发病相关性较强。ApoA-I（OR：0.173，95%CI：2.56-12.79）及HDL-C（OR：0.122，95%CI：4.57-9.26）为AD的保护性因素。结论高血压、马凡综合征、吸烟、饮酒、单纯性肾囊肿、主动脉瓣二瓣化畸形、动脉粥样硬化、UA和FFA是国人AD发病的独立危险因素，ApoA-I和HDL-C为AD的保护因素。临床医生应对危险因素予以关注。
Objective To analyze the epidemiological characteristics of risk factors of attack of aortic dissection disease （AD） in Chinese population. Methods The data of 1015 AD patients were retrospectively analyzed in 15 large-scale cardiologic centers from Jan. 1, 2011 to Dec. 31, 2012. AD patients were included into case group and 920 patients without AD at the same hospitalization time were included into control group. The data related to age, sex, body mass index （BMI）, Behcet’s disease （BD）, hypertension, blood fat and atherosclerosis was collected. Results Hypertension, Marfan’s syndrome, BD, smoking, drinking, simple renal cyst, bicuspid aortic valve, atherosclerosis, free fatty acid （FFA） and uric acid （UA） were independent risk factors of AD attack. The OR value of hypertension was 9.068, which indicated that hypertension was closely correlated to AD attack. ApoA-I （OR：0.173, 95%CI：2.56-12.79） and HDL （OR：0.122, 95%CI：4.57-9.26） were protective factors of AD attack. Conclusion Hypertension, Marfan’s syndrome, smoking, drinking, simple renal cyst, bicuspid aortic valve, atherosclerosis, UA and FFA are independent risk factors of AD attack in Chinese population, and ApoA-I and HDL are protective factors. The clinical doctors should pay attention to these risk factors.
出处
《中国循证心血管医学杂志》
2014年第4期411-415,共5页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
国家十二五支撑计划(2011BAI11B20)
关键词
国人
主动脉夹层
危险因素
Chinese population
Aortic dissection
Risk factors
