摘要
目的:系统评价前列地尔治疗慢性肾功能衰竭的有效性及安全性。方法:计算机检索知网、万方、维普、CBM、PubMed及Web of science数据库,搜集前列地尔治疗慢性肾功能衰竭的随机对照试验,检索时限为2009年1月-2019年11月,由2名研究者独立筛选文献、提取资料并评价纳入文献的偏倚风险后,采用Revman5.3软件进行资料的统计学分析。结果:共纳入23个随机对照试验,包括1874例研究对象,meta分析结果显示,常规治疗联合前列地尔降低Scr、BUN、24h尿蛋白及提高Ccr明显优于对照组,且可以改善双肾动脉内径及减少双肾动脉阻力。结论:当前证据显示,前列地尔联合常规治疗不仅可以改善肾功能,还可改善肾脏血流动力学,但受到纳入研究人数及质量的限制,上述结论尚需更多高质量的研究予以验证。
Objective:To systematically evaluate the efficacy and safety of alprolol in the treatment of chronic renal failure.Methods:Computer retrieval hownet,ten thousand party,VIP,CBM,PubMed and Web of science database,gathering top,randomized controlled trials in patients with chronic renal failure,retrieval time limit is 2009-November 2019,the two researchers independent selection literature,extract information and evaluation into the literature after the risk of bias,using Revman5.3 statistical software for data analysis.Results:A total of 23 randomized controlled trials,including 1874 subjects were included.Meta-analysis results showed that conventional treatment combined with alprotil low Scr,BUN,24 h urinary protein and improved Ccr were significantly better than the control group,and could improve the internal diameter of bilateral renal artery and reduce the resistance of bilateral renal artery.Conclusions:current evidence suggests that alprotil combined with conventional therapy can improve not only renal function but also renal hemodynamics,but the number and quality of studies included limit the need for more high-quality studies to verify this conclusion.
作者
阮冬冬
袁军
孟祥燕
陈凤
吴颖
RUAN Dong-dong;YUAN Jun;MENG Xiang-yan;CHEN Feng;WU Ying(The Clinical College of Chinese Medicine,Hubei University of Chinese Medicine;Renal Division,Department of Medicine,Hubei Provincial Hospital of Traditional Chinese Medicine/The First Clinical College,Hubei University of Chinese Medicine,430060)
出处
《农垦医学》
2020年第3期206-212,共7页
Journal of Nongken Medicine
