摘要
薇甘菊(Mikania micrantha H.B.K)是一种入侵植物,已对入侵地的健康生态环境造成不利影响;本文采用硅胶柱色谱分离纯化方法,研究薇甘菊叶的化学成分,分离得到9个化合物,分别为十三烷酸甲酯(1)、(Z)-6-十九碳烯酸(2)、植酸棕榈酸酯(3)、十六烷酸(4)、α-生育酚醌(5)、黑麦草内酯(6)、豆甾醇(7)、薇甘菊内酯(8)和二氢薇甘菊内酯(9),其中1~6均为首次从薇甘菊中分离得到。采用肉汤二倍稀释法对化合物1~9进行抑菌活性测试,结果显示化合物8和9对所测受试菌都有抑菌活性,最小抑菌浓度均为500 mg/L。
Mikania micrantha H.B.K is the most invasive plants in the world.The damage has severely affected the economic development of the invaded area;Nine compounds were isolated from the leaves of M.micrantha plants method through silica gel column chromatography,which were methyl tridecanoate(1),(Z)-6-nonadecenoic acid(2),phytyl palmitate(3),palmitic acid(4),α-tocopherolquinone(5),loliolide(6),stigmasterol(7),mikanolide(8),and dihydromikanolide(9)were isolated from leaves of M.micrantha by chromatography method.Their structures were elucidated on the basis of spectroscopic evidence.Compounds 1-6 were isolated from M.micrantha for the first time.The doubling dilution method of broth was used to test the antibacterial activity of compounds 1-9.The results showed that compounds 8 and 9 had antibacterial activity against the tested bacteria,and the minimum inhibitory concentration was 500 mg/L.
作者
马秋
王照国
杨雪
李
MA Qiu;WANG Zhao-guo;YANG Xue;LI Yan(State Key Laboratory of Functions and Applications of Medicinal Plants;The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs,Guiyang 550014,China)
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2020年第12期2061-2065,共5页
Natural Product Research and Development
基金
国家自然科学基金地区基金(31660530)
国家重点研发计划子课题(2017YFD0201402-05)
贵州省科学基金(黔科合支撑[2018]2357)。
关键词
薇甘菊
抑菌活性
化学成分
Mikania micrantha
antibacterial activity
chemical composition
