经鼻高流量吸氧和经口鼻面罩无创正压通气呼吸机在轻中度COPD合并轻中度低氧血症中运用的对比被引量：18

Comparison of high-flow nasal cannula oxygen and noninvasive ventilation in patients with mild to moderate COPD complicated with mild to moderate hypoxemia

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摘要目的探讨经鼻高流量吸氧和经口鼻面罩无创正压通气呼吸机在轻中度慢性阻塞性肺疾病(COPD)合并轻中度低氧血症中运用的对比。方法选取2018年1月至2019年1月宜昌市第一人民医院收治的轻中度COPD合并轻中度低氧血症患者46例进行回顾性研究,采用随机数字分配的方法分为对照组和研究组,各23例。对照组患者采用经口鼻面罩无创正压通气呼吸机进行治疗,研究组患者采用经鼻高流量吸氧进行治疗,对2组患者的临床治疗效果,预后效果以及气血情况进行比较。结果对照组患者的临床有效率低于研究组(69.6%比91.3%,χ^2=4.935,P<0.05)。研究组患者的并发症发生率低于对照组(χ^2=4.359,P=0.04)。研究组患者的撤机时、撤机1 h、撤机5 h的pH、动脉血氧分压、动脉血二氧化碳分压情况均明显优于对照组(P值均<0.05),2组患者撤机10 h的血气指标差异均无统计学意义(P值均>0.05)。结论对轻中度COPD合并轻中度低氧血症患者实施经鼻高流量吸氧治疗,其临床效果较为显著,预后效果理想,值得在临床上推广应用。 Objective To compare the application of high-flow nasal cannula oxygen and noninvasive ventilation in patients with mild to moderate chronic obstructive pulmonary disease(COPD)complicated with mild to moderate hypoxemia.Methods From January 2018 to January 2019,46 patients with mild to moderate COPD and mild to moderate hypoxemid admiitted to People′s Hospital of Three Gorges University were randomly divided into control group and study group with 23 cases each.The patients in the control group were treated with noninvasive ventilation,while those in the study group were treated with high-flow nasal cannula oxygen.Results The clinical effective rate of the control group was 69.6%,which was lower than that of the study group(91.3%)(χ^2=4.935,P<0.05),The incidence of complications in the study group was lower than that in the control group(χ^2=4.359,P=0.04),The pH,partial pressure of oxyenin artery and partial pressure of carbon dioxide in artery in the study group were significantly better than those in the control group(all P<0.05),There were no significant difference in blood gas analysis indexes between the two groups of patients after weaning for 10 hours(all P<0.05).Conclusions High-flow nasal cannula oxygen is the effective in the treatment of mild to moderate COPD patients with mild to moderate hypoxemia.It is worthy of clinical application.

作者苏建倪吉祥王迎难 Su Jian;Ni Jixiang;Wang Yingnan(Department of Respiratory and Critical Care,People′s Hospital of Three Gorges University,the First People′s Hospital of Yichang,Yichang 443000,China)

机构地区三峡大学人民医院

出处《国际呼吸杂志》 2020年第22期1741-1745,共5页 International Journal of Respiration

关键词预后经鼻高流量吸氧无创呼吸机轻中度慢性阻塞性肺疾病中度低氧血症 Prognosis Transnasal high-flow nasal cannula oxygen Non-invasive Suction Machine Mild to moderate chronic obstructive pulmonary disease Moderate hypoxemia

分类号 R563.9 [医药卫生—呼吸系统]