摘要
溃疡性结肠炎(UC)作为一种难治性的直结肠慢性非特异性炎症性肠病,已被WHO列为现代难治病之一,严重影响患者的正常生活。目前西医尚无明确的根治方法,而中医药在调节免疫功能、修复肠黏膜、缓解肠道炎症等方面具有独特优势。本文通过从病因病机、效方专用、中药专用、分型论治、针灸疗法、中药灌肠、穴位埋线、中药足浴等方面论述中医药治疗UC的研究进展,发现某些中药治疗UC的机理可能是通过调节T淋巴细胞亚群平衡而改善免疫功能、调节脑肠肽水平修复胃肠黏膜、抑制肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1、IL-6、IL-8、前列腺素E2(PGE2)、Toll样受体2(TLR2)mRNA及TLR2蛋白表达、降低抗中性粒细胞胞浆抗体(ANCA)含量、Smad7表达水平而缓解肠道炎症反应,针灸可能通过抑制还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶(NOXs)-活性氧簇(ROS)-NOD样受体蛋白3(NLRP3)炎症小体信号通路减轻肠黏膜损伤,穴位埋线可能通过抑制5-脂氧合酶(5-LOX)和NF-κB065的mRNA及蛋白表达减轻肠道炎症,中药灌肠、中药足浴对UC也都有一定的辅助治疗作用。因此,中医药治疗UC可有效改善患者临床症状,提高临床治疗效果,值得进一步应用和推广。
Ulcerative colitis(UC),as a refractory straight colon non-specific inflammatory bowel disease,has been listed by WHO as one of the modern refractory diseases,which seriously affects the normal life of patients.At present,there is no clear cure for Western medicine,and Chinese medicine has unique advantages in regulating immune function,repairing intestinal mucosa,and alleviating intestinal inflammation.This article discusses the research progress of traditional Chinese medicine in the treatment of UC from the aspects of etiology and pathogenesis,special prescription,traditional Chinese medicine,classification and treatment,acupuncture therapy,traditional Chinese medicine enema,acupoint embedding,traditional Chinese medicine foot bath,etc,and it was found that the mechanism of certain Chinese medicines for the treatment of UC may be to improve the immune function by regulating the balance of T lymphocyte subsets,adjust the level of brain-gut peptides to repair the gastrointestinal mucosa,inhibit tumor necrosis factor-α(TNF-α),interleukin(IL)-1,IL-6,IL-8,prostaglandin E2(PGE2),Toll-like receptor 2(TLR2)mRNA and TLR2 protein expression,reduce antineutrophil cytoplasmic Antibody(ANCA)content,Smad7 expression level and relieve intestinal inflammation,acupuncture may reduce intestinal mucosal damage by inhibiting the reduced nicotinamide adenine dinucleotide phosphate(NADPH)oxidases(NOXs)-reactive oxygen species(ROS)-NOD-like receptor protein 3(NLRP3)inflammatory body signaling pathway,acupoint embedding may reduce intestinal inflammation by inhibiting the mRNA and protein expression of 5-lipoxygenase(5-LOX)and NF-κB065.Traditional Chinese medicine enema and traditional Chinese medicine foot bath also have a certain auxiliary treatment effect on UC.Therefore,traditional Chinese medicine treatment of UC can effectively relieve the clinical symptoms of patients and improve the clinical treatment effect,which is worthy of further application and promotion.
作者
郭玲珑
姜小艳
李娟娟
张春虹
李京伟
陈建宏
黄彬
GUO Ling-long;JIANG Xiao-yan;LI Juan-juan;ZHANG Chun-hong;LI Jing-wei;CHEN Jian-hong;HUANG Bin(The Fourth Clinical Medical College,Guangzhou University of Traditional Chinese Medicine,Guangdong Province,Guangzhou510000,China;Department of Spleen and Stomach,Shenzhen Hospital of Traditional Chinese Medicine,Guangdong Province,Shenzhen518000,China)
出处
《中国当代医药》
2020年第34期26-30,共5页
China Modern Medicine
基金
黄彬广东省名中医传承工作室建设项目[粤中医办函(2020)1号]
广东省深圳市科技创新委员会知识创新计划基础研究项目(201803023000742)。
关键词
结肠炎
溃疡性
中医
中草药
综述
Colitis
Ulcerative
Chinese medicine
Chinese herbal medicine
Review
