摘要
目的探讨鼻型结外NK/T细胞淋巴瘤(ENKTL)治疗前外周血血小板/淋巴细胞比率(PLR)、中性粒细胞/淋巴细胞比率(NLR)对生存的价值。方法选取昆明医科大学第三附属医院(云南省肿瘤医院)2009年1月至2019年6月消化肿瘤内科收治的原发鼻型ENKTL患者86例作为研究对象,收集所有患者的鼻型ENKTL治疗前外周血PLR、NLR及临床数据,分析其与患者总生存期(OS)、无进展生存期(PFS)及临床特征之间的关系。结果经单因素分析结果显示,PLR与乳酸脱氢酶(LDH)、β2-微球蛋白(β2-MG)、国际预后指数(IPI)、PFS、OS相关;NLR与PFS、OS相关,差异有统计学意义(P<0.05)。经Logistic回归分析结果显示,PLR是PFS、OS的独立预后因素,差异有统计学意义(P=0.011,P=0.049),而NLR是PFS的独立预后因素,差异有统计学意义(P=0.023)。结论鼻型ENKTL治疗前外周血PLR对PFS、OS有预测价值,NLR可作为PFS的独立预后因素。
Objective To evaluate the survival value of peripheral blood platelet/lymphocyte ratio(PLR)and neutrophil/lymphocyte ratio(NLR)in patients with extranasal NK/T cell lymphoma(ENKTL)before treatment.Methods A total of 86 patients with primary nasal ENKTL admitted to the 3rd Affiliated Hospital of Kunming Medical University(Yunnan Tumor Hospital Kunming)from January 2009 to June 2019 were selected as the study subjects.The peripheral blood PLR、NLR and clinical data of all patients with nasal ENKTL were collected.To analyze the relationship between total survival(OS),progression-free survival(PFS)and clinical features.Results Univariate analysis showed that PLR was correlated with LDH,β2-MG,IPI,PFS,OS,NLR with PFS,OS and the difference was statistically significant meaning(P<0.05).Logistic regression analysis,PLR was an independent prognostic factor for PFS,OS,and the difference was statistically significant(P=0.011,P=0.049),while NLR was an independent prognostic factor for PFS,the difference was statistically significant(P=0.023).Conclusion Peripheral blood PLR before nasal ENKTL treatment has predictive value for PFS,OS and can NLR be used as an independent prognostic factor for PFS.
作者
邓明佳
李昱霖
易子寒
DENG Mingjia;LI Yulin;YI Zihan(The 3rd Affiliated Hospital of Kunming Medical University(Yunnan Tumor Hospital Kunming),Kunming,Yunnan 650118,China)
出处
《大医生》
2020年第16期4-7,共4页
Doctor
