摘要
目的探究甲亢患者应用甲巯咪唑+普萘洛尔治疗的临床效果。方法选取2019年1月至12月甘肃省白银市中西医结合医院收治的74例甲亢患者,依据抽签法将患者分为对照组和试验组,各37例。对照组患者采用甲巯咪唑治疗,试验组患者采用甲巯咪唑+普萘洛尔治疗,对比两组患者治疗前后游离三碘甲状腺原氨酸、游离甲状腺激素、血清促甲状腺激素水平、临床治疗有效率、用药不良反应等指标。结果治疗前,两组患者甲状腺分泌物指标水平比较,差异无统计学意义(P>0.05),治疗后,试验组患者游离三碘甲状腺原氨酸、游离甲状腺激素、血清促甲状腺激素水平数值分别为(6.94±0.31)pmol/mL、(20.49±0.35)pmol/mL、(0.31±0.02)pmol/mL,对照组数值分别为(10.57±0.28)pmol/mL、(26.46±0.48)pmol/mL、(0.19±0.02)pmol/mL,治疗后试验组甲状腺分泌物指标改善幅度更大(P<0.05)。试验组治疗总有效率为97.30%,显著高于对照组(P<0.05)。两组患者不良反应的发生率差异无统计学意义(P>0.05)。结论甲亢患者采用甲巯咪唑联合普萘洛尔治疗方案,可以有效改善患者的甲状腺功能以及甲亢症状。
Objective To explore the clinical effect of methimazole+propranolol treatment in patients with hyperthyroidism.Methods From January to December 2019,74 patients with hyperthyroidism admitted to Baiyin Hospital of Integrated Traditional Chinese and Western Medicine were selected and divided into control group and experimental group according to the lottery method,37 cases each.The control group was treated with methimazole,while the experimental group was treated with methimazole+propranolol.Indicators such as free triiodothyronine,free thyroid hormone,serum thyrotropin level,effective rate of clinical treatment,adverse drug reactions and so on were compared between the two groups before and after treatment.Results There was no statistically significant difference in the levels of thyroid secretion between the two groups before treatment(P>0.05).After treatment,the levels of free triiodothyronine,free thyroid hormone and serum thyrotropin in the test group were(6.94±0.31)pmol/mL,(20.49±0.35)pmol/mL and(0.31±0.02)pmol/mL,respectively.The values of the control group were(10.57±0.28)pmol/mL,(26.46±0.48)pmol/mL,and(0.19±0.02)pmol/mL,respectively.After treatment,the thyroid secretion index of the test group improved significantly(P<0.05).The clinical effective rate of the experimental group was 97.30%,which was significantly higher than that of the control group(P<0.05).Adverse reactions of the two groups were similar(P>0.05).Conclusion Methimazole combined with propranolol can effectively improve thyroid function and hyperthyroidism symptoms in patients with hyperthyroidism.
作者
白红霞
BAI Hongxia(Baiyin Hospital of Integrated Traditional Chinese and Western Medicine,Baiyin,Gansu 730900,China)
出处
《大医生》
2020年第17期94-96,共3页
Doctor
关键词
甲巯咪唑
普萘洛尔
甲亢
methimazole
propranolol
hyperthyroidism
