摘要
目的探讨对子宫动脉搏动指数(UtA-PI)、可溶性FMS样酪氨酸激酶-1(sFlt-1)与胎盘生长因子(PlGF)水平比值预测系统性红斑狼疮(SLE)妊娠患者胎盘功能障碍相关不良妊娠的有效性。方法选取2017年7月至2019年7月解放军联勤保障第901医院和承德医学院附属医院接诊的40名SLE妊娠患者作为研究对象。所有患者按照妊娠结局分为正常结局组(n=32)、SLE发作组(n=4)和不良妊娠组(n=4)。分别于孕早期(<13周)、孕中期(13~27周)、孕晚期(>27周)检测所有患者sFlt-1和PlGF水平,并通过子宫动脉多普勒超声检测UtA-PI。对三组患者的检测值进行比较。结果孕早期时,三组UtAPI和sFlt-1/PlGF组间比较,差异无统计学意义(P>0.05)。不良妊娠组的UtA-PI水平在孕中期和孕晚期均高于正常结局组和SLE发作组,差异均具有统计学意义(均P<0.05);不良妊娠组sFlt-1/PlGF水平在孕晚期显著高于正常结局组和SLE发作组,差异具有统计学意义(P<0.05)。SLE发作组和不良妊娠组患者分娩时的孕周短于正常结局组,34周前分娩发生率高于正常结局组,新生儿体重低于正常结局组,差异均具有统计学意义(均P<0.05)。不良妊娠组低体重儿发生率显著高于正常结局组,5分钟时Apgar评分低于正常结局组,差异均具有统计学意义(均P<0.05)。结论UtA-PI和sFlt-1/PlGF检测有助于预测SLE妊娠患者不良结局。
Objective To evaluate the effectiveness of the uterine artery pulsatility index(UtA-PI)and the sFlt-1/PlGF ratio on predicting the adverse outcomes associated with placental dysfunction in patients with systemic lupus erythematosus(SLE).Methods 40 pregnancy patients with SLE treated by the 901 Hospital of PLA Joint Service Support and the Affiliated Hospital of Chengde Medical College from July 2017 to July 2019,were selected as study subjects.According to pregnancy outcomes,all patients were divided into normal outcome group(n=32),SLE attack group(n=4)and adverse pregnancy group(n=4).The levels of sFlt-1 and PlGF were respectively detected in all patients at the first trimester(<13 weeks),the second trimester(13-27 weeks)and the third trimester(>27 weeks).UtA-PI was detected by uterine artery doppler ultrasonography.The comparison of the results between three groups was made.Results In the first trimester,there was no significant difference in UtA-PI and sFlt-1/PlGF between three groups(P>0.05).The UtA-PI values of the adverse pregnancy group in the second and third trimesters were higher than those of the normal outcome group and SLE group,and the differences were statistically significant(all P<0.05).The level of sFlt-1/PlGF in the adverse pregnancy group was significantly higher in the third trimester than that in the normal outcome group and SLE group,with statistically significant difference(P<0.05).The gestational weeks at delivery of patients in SLE attack group and adverse pregnancy group were shorter than those in the normal outcome group,the incidence of delivery at 34 weeks was higher than that in the normal outcome group,and the newborn weight was lower than that in the normal outcome group,with statistically significant differences(all P<0.05).The incidence of low weight infants in the adverse pregnancy group was significantly higher than that in the normal outcome group,and the Apgar score at 5 minutes was lower than that in the normal outcome group,with statistically significant differences(all P<
作者
许成琼
李大梅
陈露露
张玉芳
XU Chengqiong;LI Damei;CHEN Lulu;ZHANG Yufang(Department of Obstetrics and Gynecology,901 Hospital of PLA Joint Service Support,Hefei,230031,Anhui,China;Department of Obstetrics and Gynecology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China)
出处
《中国性科学》
2020年第11期54-58,共5页
Chinese Journal of Human Sexuality
基金
河北省医学科学研究重点课题指令项目(20160017)。
关键词
系统性红斑狼疮
妊娠
不良结局
子宫动脉搏动指数
Systemic lupus erythematosus
Pregnancy
Adverse outcome
Uterine artery pulsatility index
