摘要
目的探讨扎那米韦联合豉翘清热颗粒在儿童急性上呼吸道感染治疗中的应用价值及疗效影响因素。方法选择2017年1月—2018年12月100例儿童急性上呼吸道感染患者,然后将其设定为研究对象,回顾性研究上述患者的临床病历资料。其中对照组48例,予以扎那米韦治疗。观察组52例,使用扎那米韦外,同时使用豉翘清热颗粒治疗。观察并比较两组的治疗效果。同时根据上述患者治疗疗效情况,将其分为有效组(n=66)与无效组(n=34),并通过cox回归模型分析影响患者预后的危险因素。结果 (1)两组患者血清TNF-α、IL-10、IL-6水平治疗前差异无统计学意义(P>0.05),观察组通过治疗后上述指标比对照组更优(P<0.05)。(2)两组患者血清白细胞计数、血沉及HS-CRP水平治疗前差异无统计学意义(P>0.05)。观察组通过治疗后上述指标比对照组更低(P<0.05)。(3)两组患者血清触珠蛋白、降钙素原与前白蛋白水平治疗前差别不明显(P>0.05)。观察组通过治疗后上述指标比对照组更优(P<0.05)。(4)观察组症状(咳嗽、发烧、腹泻、咽喉红肿、鼻塞流涕)消失时间相较对照组明显更短(P<0.05)。(5)观察组总有效率相较对照组明显更高(P<0.05)。(6)cox回归分析结果表明,维生素A、维生素D、贫血、CK-MB、α-HBD均为影响儿童急性上呼吸道感染的疗效的独立危险因素。结论扎那米韦联合豉翘清热颗粒应用于儿童急性上呼吸道感染的治疗,能明显降低患者炎性水平,并有效改善患者症状,治疗效果显著。另外,针对患者维生素A、维生素D、贫血、CK-MB、α-HBD等独立危险因素,应及时采取预防措施,增加治疗效果。
Objective To study the application value of zanamivir combined with Chiqiao Qingre Granule in the treatment of acute upper respiratory tract infection in children and analyze influencing factors about efficiency. Methods A total of 100 children with acute upper respiratory tract infection in hospital were treated from 2017 January to 2018 December. Their clinical data was analyzed retrospectively. They were divided into observation group(n=52) and control group(n=48). The patients were treated with zanamivir and Chiqiao Qingre Granule in the observation group, while the patients were treated with zanamivir in the control group. The treatment effects were observed and compared. At the same time, according to the treatment efficiency of these patients, they were divided into efficiency group(n=66) and non-efficiency group(n=34), and the risk factors of efficiency were analyzed by cox regression model. Results(1)There was no significant difference about the levels of TNF-α, IL-10 or IL-6 in serum between the two groups before treatment(P>0.05), but the above indexes in the observation group were better than those in the control group after treatment(P<0.05).(2)There was no significant difference about white blood cell count, erythrocyte sedimentation rate or HS-CRP in serum between the two groups before treatment(P>0.05). After treatment, the above indexes in the observation group were lower than those in the control group(P<0.05).(3)There was no significant difference about contact globin, procalcitonin or prealbumin in serum between the two groups before treatment(P>0.05). After treatment, the above indexes in the observation group were better than those in the control group(P<0.05).(4)The disappearance time of symptoms(cough, fever, diarrhea, redness and swelling of throat, runny nose) in the observation group was significantly shorter than that in the control group(P<0.05).(5)The effective rate of the observation group was higher than that of the control group(P<0.05).(6)According to cox regression analysis, it
作者
张长玲
刘文君
刘春艳
肖兰
ZHANG Changling;LIU Wenjun;LIU Chunyan;XIAO Lan(Department of Pediatrics,Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China;Sichuan Provincial Clinical Medical Center for Birth Defects,Luzhou 646000,Sichuan,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第11期210-214,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家卫生计生委科技计划(W2016EWSC04)。
关键词
扎那米韦
豉翘清热颗粒
儿童急性上呼吸道感
治疗效果
影响因素
zanamivir
Chiqiao Qingre Granule
acute upper respiratory tract infection in children
treatment effect
influencing factors
