摘要
目的探讨血清触珠蛋白(Hp)水平在儿童上呼吸道感染诊断中的临床意义。方法选取204例上呼吸道感染患儿和100例健康体检儿童作为研究对象,测定其血清Hp和C反应蛋白(CRP)水平并进行WBC。根据CRP和WBC水平,上呼吸道感染儿童分为CRP升高组102例与正常组102例、WBC升高组86例与正常组118例,并对各组资料进行统计学分析。结果与健康对照组相比,上呼吸道感染组Hp、CRP和WBC水平均明显增高,差异均有统计学意义(均P<0.05)。CRP升高组血清Hp水平高于CRP正常组(P<0.01),WBC升高组血清Hp水平高于WBC正常组(P<0.01),两者比较差异均有统计学意义。Hp用于诊断上呼吸道感染的ROC曲线AUC(0.853)高于CRP(0.834)、WBC(0.633),当以Hp=66.3μg/ml为cut-off值时,灵敏度为0.887,特异度为0.540。结论 Hp属炎症急性期蛋白,Hp水平可作为辅助诊断小儿上呼吸道感染的一个参考指标。
Objective To investigate the serum Two levels of and haptoglobin（Hp）with in children URTI with 100 upper healthy respiratory children tract infection（URTI）were and its clinical significance.levels Methods hundred four and children white and（control group）subjects.enrolled.Serum levels of Hp and CRP,C-and reactive WBC protein URTI（CRP）group blood cell count（WBC）were in measured in Hp all Results 0.01）.higher Serum The of Hp were and in were URTI significantly group.higher area than those healthy control group（all P（0.853）levels of of Hp correlated with CRP and WBC in The under the ROC curve（AUC）of was than that and CRP（0.834）was and WBC and（0.633）for diagnosing URTI.When the cutoff Serum value of Hp was level set might at 66.3μg/ml,serve its new sensitivity reference specificity 0.887 of 0.540 for diagnosis of URTI.Conclusion haptoglobin as a index for diagnosis URTI in children.
作者
赵昕峰
吴亦栋
陈刚
高扬
张利华
ZHAO Xinfeng;WU Yidong;CHEN Gang(Department of Clinical laboratory,Hangzhou Children＇s Hospital,Hangzhou 310014,China)
出处
《浙江医学》
CAS
2018年第16期1830-1832,共3页
Zhejiang Medical Journal
关键词
触珠蛋白
上呼吸道感染
C反应蛋白
白细胞计数
Haptoglobin
Upper respiratory tract infection
C reactive protein
Whiteblood cell count
