摘要
湿热证是临床常见的实证,也是近年研究的热点,代谢组学技术在阐明湿热证本质方面具有巨大潜力。文章从临床研究、实验研究方面,对基于代谢组学的湿热证研究相关文献进行了梳理,发现慢性胃炎、肝病的研究较多,研究的样本主要是血液、尿液和唾液,许多文献都报道了筛选出的湿热证差异代谢物,为湿热证的客观化做出了贡献,但又存在以下缺点:多数研究未排除饮食等混杂因素的影响,研究仍停留在湿热证与差异代谢物相关性的层面以及未对差异代谢物进行验证,并且目前暂无湿热证的粪便代谢组学研究等。克服这些缺点,必将对有助于促进湿热证的本质研究。
Damp-heat syndrome is a common clinical demonstration,and also a hotspot of research in recent years.Metabolomics technology has great potential in elucidation of the essence of damp-heat syndrome.Based on clinical research and experimental research,this paper reviewed the relevant literatures on the research of damp-heat syndrome based on metabolomics.It was found that there were many studies on chronic gastritis and liver disease,and the samples were mainly blood,urine and saliva.Many literatures have reported the screened differential metabolites of damp-heat syndrome,which has made some contributions to the objectification of damp-heat syndrome,but has the following shortcomings:most studies don’t exclude the influence of confounding factors such as diet and the research still remains at the level of correlation between damp-heat syndrome and differential metabolites,and has not verified the differential metabolites,and currently there are no fecal metabolomics studies with damp-heat syndrome.Overcoming these shortcomings will certainly help to promote the essence of damp-heat syndrome research.
作者
朱春梅
杨德才
曹阳
王忆勤
刘国萍
ZHU Chun-mei;YANG De-cai;CAO Yang;WANG Yi-qin;LIU Guo-ping(Basic Medical College,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第10期5077-5080,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81873236,No.81270050)
国家中医药管理局第四批全国中医(临床、基础)优秀人才项目(2017年)
上海市健康辨识与评估重点实验室(No.13DZ2261000)。
关键词
湿热证
代谢组学
综述
差异代谢物
实验研究
临床研究
Damp-heat syndrome
Metabonomics
Review
Differential metabolites
Experimental research
Clinical research
