摘要
目的观察双歧杆菌三联活菌联合复方胃蛋白酶治疗婴幼儿支气管肺炎继发性腹泻的临床效果。方法选取温岭市第四人民医院儿科2018年1-12月收治的婴幼儿支气管肺炎继发性腹泻患儿100例,采用随机数字表法分为对照组(n=50)及观察组(n=50),对照组采用双歧杆菌三联活菌治疗,观察组采用双歧杆菌三联活菌联合复方胃蛋白酶治疗,对比两组的临床疗效、腹泻消失时间与住院时间、炎性因子水平[白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]以及血清学指标[胃泌素(GAS)、胃动素(MOT)、生长抑素(SS)、二胺氧化酶(DAO)]。结果观察组总有效率(96.0%)高于对照组(82.0%)(χ2=4.184,P<0.05);观察组腹泻消失时间、住院时间分别为(2.5±1.0)d、(3.6±0.6)d,均短于对照组的(4.1±1.3)d、(5.7±0.8)d(t=3.762、2.541,均P<0.05);观察组治疗后IL-6、TNF-α分别为(10.5±2.1)ng/L、(12.6±3.5)ng/L,均低于对照组的(16.6±2.5)ng/L、(21.2±4.4)ng/L(t=5.129、6.118,均P<0.05);观察组治疗后的GA、MOT、SS、DAO分别为(86.8±8.4)ng/L、(386.1±32.2)ng/L、(51.5±7.2)ng/L、(1.0±0.3)U/mL,均优于对照组的(115.4±10.1)ng/L、(502.8±41.6)ng/L、(37.3±5.8)ng/L、(1.4±0.5)U/mL(t=6.310、21.576、10.964、5.683,均P<0.05)。结论双歧杆菌三联活菌联合复方胃蛋白酶治疗婴幼儿支气管肺炎继发性腹泻的临床效果显著,可缩短腹泻消失时间、住院时间,降低炎性因子水平,改善血清学指标。
ObjectiveTo observe the clinical effect of Bifidobacterium combined with compound pepsin powder in the treatment of secondary diarrhea following bronchopneumonia in infants,so as to explore the best clinical treatment of the disease and promote the early recovery of children.MethodsFrom January 2018 to December 2018,100 infants with secondary diarrhea following bronchopneumonia who admitted to Department of Pediatrics of the Fourth People's Hospital of Wenling were divided into group A(n=50)and group B(n=50)according to random number table method.Bifidobacterium treatment and Bifidobacterium combined with compound pepsin powder were given,respectively.The clinical efficacy,disappearance time of diarrhea and hospitalization time,levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factorα(TNF-α)]and serological indicators[gastrin(GAS),plasma motilin(MOT),somatostatin(SS),diamine oxidase(DAO)]were compared between the two groups.ResultsThe total effective rate of group B(96.0%)was higher than that of group A(82.0%)(χ2=4.184,P<0.05).The disappearance time of diarrhea and hospitalization time in group B[(2.5±1.0)d,(3.6±0.6)d]were shorter than those in group A[(4.1±1.3)d,(5.7±0.8)d](t=3.762,2.541,all P<0.05).The levels of IL-6 and TNF-in the group B[(10.5±2.1)ng/L,(12.6±3.5)ng/L]were lower than those in group A[(16.6±2.5)ng/L,(21.2±4.4)ng/L](t=5.129,6.118,all P<0.05).After treatment,the levels of GAS,MOT,SS,DAO in group B[(86.8±8.4)ng/L,(386.1±32.2)ng/L,(51.5±7.2)ng/L,(1.0±0.3)U/mL]were better than those in group A[(115.4±10.1)ng/L,(502.8±41.6)ng/L,(37.3±5.8)ng/L,(1.4±0.5)U/mL](t=6.310,21.576,10.964,5.683,all P<0.05).ConclusionBifidobacterium combined with compound pepsinase powder is effective in the treatment of infantile secondary diarrhea following bronchopneumonia.It can significantly shorten the disappearance time of diarrhea and hospitalization time,reduce the levels of inflammatory factors and improve serological indicators.It is worthy of implementation.
作者
王金凤
应如芬
林信良
Wang Jinfeng;Ying Rufen;Lin Xinliang(Department of Pediatrics,the Fourth People's Hospital of Wenling,Wenling,Zhejiang 317511,China)
出处
《中国基层医药》
CAS
2020年第21期2650-2654,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
双歧杆菌
复方胃蛋白酶散
支气管肺炎
继发性腹泻
炎症因子
血清学指标
治疗有效率
白细胞介素
肿瘤坏死因子
Bifidobacterium
Compound pepsin powder
Bronchopneumonia
Secondary diarrhea
Level of inflammatory factors
Serological indicators
Therapeutic efficacy
Interleukin
Tumor necrosis factor
