摘要
目的分析阿奇霉素序贯疗法用于小儿肺炎支原体肺炎的效果.方法选取我院2021年6月—2023年5月收治的200例小儿肺炎支原体肺炎患儿为研究对象,采用随机数字表法将其分为对照组和试验组,各100例.对照组采用红霉素序贯疗法治疗,试验组采用阿奇霉素序贯疗法治疗,两组均治疗14 d.对比两组的炎症因子水平、症状缓解时间、治疗效果和不良反应发生情况.结果治疗前,两组炎症因子水平比较,差异无统计学意义(P>0.05);治疗14d后,试验组的肿瘤坏死因子-α为(7.13±1.28)ng/mL,白细胞介素-6为(61.32±2.35)pg/mL,超敏C反应蛋白为(1.31±0.28)mg/L,均低于对照组的(9.24±1.58)ng/mL、(84.48±2.17)pg/mL、(2.16±0.23)mg/L,组间差异有统计学意义(P<0.05).试验组的发热、咳嗽、肺部湿啰音缓解时间均短于对照组,组间差异有统计学意义(P<0.05).试验组治疗总有效率为99.00%,高于对照组的85.00%,差异有统计学意义(P<0.05).试验组不良反应发生率为2.00%,低于对照组的10.00%,差异有统计学意义(P<0.05).结论阿奇霉素序贯疗法应用于小儿肺炎支原体肺炎中的临床效果较好,能提升患儿的疾病控制程度,使其临床症状尽快消除,且不良反应少.
Objective To analyze the effect of azithromycin sequential therapy on mycoplasma pneumoniae pneumonia in children.Methods 200 children with Mycoplasma pneumoniae pneumonia admitted to our hospital from June 2021 to May 2023 were selected as the research subjects.They were randomly divided into a control group and an experimental group using a random number table method,with 100 cases in each group.The control group was treated with erythromycin sequential therapy,while the experimental group was treated with azithromycin sequential therapy.Both groups were treated for 14 days.The levels of inflammatory factors,the time of symptom relief,the treatment effect and the incidence of adverse reactions were compared.Results Before treatment,there was no statistically significant difference in the levels of inflammatory factors between the two groups(P>0.05);after 14 days of treatment,the level of tumor necrosis factor-αwas(7.13±1.28)ng/mL,the level of interleukin-6 was(61.32±2.35)pg/mL,and the level of hypersensitive C-reactive protein was(1.31±0.28)mg/L in the experimental group,which were lower than(9.24±1.58)ng/mL,(84.48±2.17)pg/mL,and(2.16±0.23)mg/L in the control group,with statistically significant differences between the groups(P<0.05).The relief time for fever,cough,and lung moist rales in the experimental group were shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05).The total effective rate of the experimental group was 99.00%,which was higher than the control group's 85.00%,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 2.00%,lower than the control group's 10.00%,and the difference was statistically significant(P<0.05).Conclusion Azithromycin sequential therapy has a good clinical effect in children with mycoplasma pneumoniae pneumonia,which can improve the degree of disease control of children and eliminate their clinical symptoms as soon as possible,with few adv
作者
李艳凤
何国平
赵延发
LI Yanfeng;HE Guoping;ZHAO Yanfa(Department of Pediatric,Wenshang County People's Hospital,Jining Shandong,272500,China)
出处
《反射疗法与康复医学》
2024年第6期70-73,共4页
Reflexology And Rehabilitation Medicine
关键词
肺炎支原体肺炎
阿奇霉素序贯疗法
红霉素序贯疗法
临床效果
安全性
炎症因子
Mycoplasma pneumoniae pneumonia
Azithromycin sequential therapy
Erythromycin sequential therapy
Clinical effect
Security
Inflammatory factor
