摘要
乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)是乙型肝炎病毒(hepatitis B virus,HBV)感染的标志。近年有关表面抗原生物学功能的研究日趋深入,其在介导病毒黏附和侵入,诱导内质网应激和细胞凋亡,参与细胞免疫应答等方面都具有重要的作用。本文通过对HBsAg生物学功能进行综述,以期为乙型肝炎治愈研究提供新的思路。
Hepatitis B virus surface antigen(HBsAg)is a marker of hepatitis B virus infection.In recent years,progress has been made in the function of HBsAg which plays an important role in mediating viral adhesion and invasion,endoplasmic reticulum stress and cellular immunity.HBsAg is of great significance for the study of HBV vaccines and therapeutic vaccines.In this review,we summarize recent progress on the functions of HBsAg.
作者
谢培琳
张欣欣
XIE Pei-lin;ZHANG Xin-xin(Research Laboratory of Clinical Virology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China)
出处
《中国病毒病杂志》
CAS
2020年第5期333-336,共4页
Chinese Journal of Viral Diseases
基金
国家“十三五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2017ZX10202202)。
关键词
乙型肝炎表面抗原
病毒黏附侵入
内质网应激
细胞免疫
Hepatitis B virus surface antigen
Viral adhesion and invasion
Endoplasmic reticulum stress
Cellular immunity
