摘要
目的:探讨慢性心力衰竭患者血浆组织型金属蛋白酶抑制剂-4(TIMP-4)、可溶性E-选择素(sES)和游离脂肪酸(FFA)的动态变化的临床意义。方法:选择本院2017年1月-2018年12月诊治的CHF患者94例,测定患者TIMP-4、sES、FFA动态变化。结果:重度患者TIMP-4显著低于轻度患者,sES、FFA显著高于轻度患者(P<0.05);治疗后患者TIMP-4逐渐升高,sES、FFA逐渐降低(P<0.05);存活患者TIMP-4显著高于死亡患者,sES、FFA显著低于死亡患者(P<0.05)。结论:针对CHF患者加强TIMP-4、sES、FFA定期检测是判断病情及预测预后的可靠依据,具有较高临床价值,值得临床借鉴。
Objective:To investigate the clinical significance of the dynamic changes of plasma tissue metalloproteinase inhibitor-4(TIMP-4),soluble Eselectin(sES)and free fatty acids(FFA)in patients with chronic heart failure.Method:A total of 94 CHF patients admitted in our hospital from January 2017 to December 2018 were selected as data to determine the dynamic changes of TIMP-4,sES,FFA in patients.Result:The TIMP-4 of severe patients was significantly lower than that of mild patients,sES,FFA were significantly higher than those of mild patients(P<0.05).After treatment,the TIMP-4 of patients gradually increased,sES,FFA gradually decreased(P<0.05).Survival patients TIMP-4 significantly higher than death patients,sES,FFA significantly lower than death patients(P<0.05).Conclusion:Strengthen TIMP-4,sES,FFA regular detection for CHF patients is a reliable basis for judging the condition and predicting the prognosis,which has high clinical value and is worthy of clinical reference.
作者
赵智慧
郝顺心
ZHAO Zhihui;HAO Shunxin(Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430064,China)
出处
《中外医学研究》
2020年第33期184-186,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
