摘要
目的探究血清免疫球蛋白G Fc段受体Ⅰ(FCGR1A)mRNA、白细胞介素⁃6(IL⁃6)、降钙素原和超敏C反应蛋白(hs⁃CRP)水平检测在诊断病人肺部感染中的应用。方法选取2018年1—12月湖南中医药高等专科学校附属第一医院呼吸科收治肺部感染病人135例,其中61例为病毒感染,74例为细菌感染,并招募同期入该院体检的健康者50例作为对照组,分析血清FC⁃GR1A mRNA、IL⁃6、降钙素原和hs⁃CRP单独及联合检测在诊断病人肺部感染中的应用价值。结果三组受试者血清FC⁃GR1A mRNA、IL⁃6、降钙素原和hs⁃CRP水平比较差异有统计学意义(P<0.05);与对照组比较,细菌感染组和病毒感染组病人血清FCGR1A mRNA、IL⁃6、降钙素原和hs⁃CRP水平均显著升高(P<0.05),且细菌感染病人上述因子水平均高于病毒感染者(P<0.05);对照组和病毒感染组,联合检测曲线下面积(AUC)为0.791,灵敏度为70.00%,特异度为80.30%,95%CI为0.705~0.877;对照组和细菌感染组,联合检测AUC为0.879,灵敏度为90.00%,特异度为86.50%,95%CI为0.815~0.943;病毒感染组和细菌感染组,联合检测AUC为0.837,灵敏度为91.80%,特异度为82.40%,95%CI为0.760~0.913;74例细菌感染病人中36例为革兰阳性菌(G^+)感染,38例为革兰阴性菌(G^⁃)感染;G^+和G^⁃病人血清FCGR1A mRNA、IL⁃6、降钙素原和hs⁃CRP水平差异无统计学意义(P>0.05)。结论应用血清FCGR1A mRNA、IL⁃6、降钙素原及hs⁃CRP联合检测对病人肺部细菌和病毒感染的诊断价值较高,但无法鉴别G^+感染和G^⁃感染。
Objective To explore the application of detecting serum high affinity immunoglobulingamma Fc receptor I(IFCGR1A)mRNA,interleukin⁃6(IL⁃6),procalcitonin(PCT)and high⁃sensitivity C⁃reactive protein(hs⁃CRP)levels in the diagnosis of lung infection in patients.Methods A total of 135 patients with lung infections who were admitted to respiratory department of First Af⁃filiated Hospital of Hunan Chinese Medicine College from January to December 2018 were enrolled,including 61 cases with virus infection and 74 cases with bacterial infection.Another 50 healthy people who underwent physical examination in the hospital dur⁃ing the same period were enrolled as control group.The application value of serum FCGR1A mRNA,IL⁃6,PCT and hs⁃CRP alone and their combination in the diagnosis of lung infection in patients was analyzed.Results There were significant differences in lev⁃els of serum FCGR1A mRNA,IL⁃6,PCT and hs⁃CRP among the three groups(P<0.05).Compared with control group,levels of se⁃rum FCGR1A mRNA,IL⁃6,PCT and hs⁃CRP were significantly increased in bacterial infection group and virus infection group(P<0.05).The levels of the above factors in bacterial infection patients were higher than those with virus infection(P<0.05).In con⁃trol group and virus infection group,area under the ROC curve(AUC),sensitivity,specificity and 95%CI of combination detection were 0.791,70.00%,80.30%and 0.705-0.877,respectively.In control group and bacterial infection group,the above 4 indexes were 0.879,90.00%,86.50%and 0.815-0.943,respectively.In virus infection group and bacterial infection group,the above 4 indexes were 0.837,91.80%,82.40%and 0.760-0.913,respectively.In the 74 cases with bacterial infection,there were 36 cases with Gram⁃positive(G^+)infection,38 cases with Gram⁃negative bacteria(G^⁃)infection.There were no significant differences in levels of serum FCGR1A mRNA,IL⁃6,PCT and hs⁃CRP between G^+and G^⁃patient(P>0.05).Conclusion The diagnostic value of combination detection with serum F
作者
莫祚群
张新果
王明明
MO Zuoqun;ZHANG Xinguo;WANG Mingming(Laboratory Department,First Affiliated Hospital of Hunan Chinese Medicine College(Hunan Provincial Hospital of Traditional Chinese Medicine),Zhuzhou,Hunan 412000,China)
出处
《安徽医药》
CAS
2020年第12期2402-2406,I0002,共6页
Anhui Medical and Pharmaceutical Journal
