摘要
目的探讨血清降钙素原(PCT)和超敏C反应蛋白(hs-CRP)在新生儿全身炎症反应综合征(SIRS)的临床价值。方法 68例SIRS新生儿,其中细菌感染组42例和非细菌感染组26例,按新生儿危重病例评分法评分分为非危重组、危重组、极危重组,检测治疗前后血清PCT、hs-CRP水平并进行分析。结果 SIRS新生儿血清PCT、hs-CRP水平均高于对照组,细菌感染组PCT水平与非细菌感染组比较差异有统计学意义(P<0.01),而两组间hs-CRP差异无统计学意义(P>0.05),经过有效治疗后,SIRS患儿的PCT、hs-CRP水平均明显下降,危重程度越高其PCT值越高。结论 PCT有助于识别感染性和非感染性SIRS,动态监测PCT,对判断感染程度、疾病预后和疗效均有帮助,是细菌感染性疾病理想的生物指标。
Objective To investigate the application value of serum PCT,hs-CRP levels and in the systemic inflammatory response syndrome（ SIRS） with Newborns. Methods 68 neonates with SIRS were chosed to investigated,SIRS groups were divided into bacterial infection group（ 42cases） and the non-bacterial infection group（ 26cases）,and grading by neonatal critical illness score,these neonates also divided into non critical group,critical group,extremely critical group,the levels of serum PCT,hsCRP in those neonates were measured before and after treatment. Results The levels of serum PCT,hs-CRP levels in all neonates with SIRS are higher than those in the control group,but compared with non-bacterial infection group,the PCT level were significant difference（ P〈0. 01） in bacterial infection group,while the hs-CRP level shoned no difference between the two groups（ P〈0. 05）,after effective treatment,both PCT and hs-CRP level were significantly decreased in all children with SIRS,and the level of PCT but not hs-CRP was related to the critical degree. Conclusion PCT coulde be used as an indicator to identify infectious and non-infectious SIRS,and dynamic monitoring the level of PCT help to determine the extent of infection,disease prognosis and treatment efficacy,which is an ideal biological indicators of bacterial infections.
出处
《四川医学》
CAS
2015年第7期1017-1019,共3页
Sichuan Medical Journal
关键词
降钙素原
超敏C反应蛋白
新生儿
全身炎症反应综合症
procalcitonin
high-sensitivity C-reactive protein
newborn
systemic inflammatory response syndrome
