摘要
目的分析白头翁汤口服联合美沙拉嗪汤灌肠治疗溃疡性结肠炎(UC)的效果。方法将2017年1月—2019年5月河北省唐山市丰润区人民医院收治的120例UC患者按随机数字表法分为对照组和治疗组,各60例。对照组予以美沙拉嗪灌肠治疗,治疗组在对照组的基础上联合口服白头翁汤治疗,疗程12周。比较两组治疗前后中医症状评分、外周血免疫功能、体液免疫水平、血清炎症因子水平、炎性肠病生活质量问卷(IBDQ),并记录治疗期间的不良反应发生情况。结果治疗后,两组中医症状评分、CD8+、IgM、IgA、IgG、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)均显著低于治疗前,且治疗组均低于对照组(均P<0.05);两组CD4+、自然杀伤细胞(NK细胞)、CD4+/CD8+、IBDQ评分均显著高于治疗前,且治疗组均高于对照组(均P<0.05)。两组治疗期间无明显不良反应发生。结论白头翁汤口服联合美沙拉嗪灌肠治疗UC的效果优于单药美沙拉嗪汤灌肠,且安全性良好。
Objective To analyze the effects of oral Baitouweng Decoction combined with Mesalazine enema in the treatment of ulcerative colitis(UC).Methods One hundred and twenty patients with UC admitted to Fengrun People’s Hospital of Tangshan City from January 2017 to May 2019 were divided into control group and treatment group according to the random number table method,with 60 cases in each group.The control group was treated with Mesalazine enema,while the treatment group was treated with oral Baitouweng Decoction on the basis of the control group,with 12 weeks of treatment course.The TCM symptom scores,peripheral immune function,humoral immunity level,serum inflammatory factor levels,inflammatory bowel disease questionnaire(IBDQ)before and after treatment were compared between the two groups,and the adverse reactions during treatment were recorded.Results After treatment,the TCM symptom scores,CD8+,IgM,IgA and IgG,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in the two groups were lower than those before treatment,which in the treatment group were significantly lower than those in the control group(all P<0.05);the CD4+,natural killer cells(NK cells),CD4+/CD8+,the scores of IBDQ in the two groups were higher than those before treatment,which in the treatment group were significantly higher than those in the control group(all P<0.05).No obvious adverse reactions occurred during the treatment of the two groups.Conclusion The efficacy of oral Baitouweng Decoction combined with Mesalazine enema in the treatment of UC is better than single-agent Mesalamine enema,and the safety is good.
作者
聂珍静
申文静
姚蕊
王欣蕾
NIE Zhenjing;SHEN Wenjing;YAO Rui;WANG Xinlei(Department of Gastroenterology,Fengrun People’s Hospital of Tangshan City,Hebei Province,Tangshan064000,China)
出处
《中国医药导报》
CAS
2020年第33期149-152,169,共5页
China Medical Herald
基金
河北省中医药管理局中医药类科研计划项目(2020401)。
关键词
白头翁汤
美沙拉嗪
灌肠
溃疡性结肠炎
疗效
Baitouweng Decoction
Mesalazine
Enema
Ulcerative colitis
Efficacy
