摘要
目的探讨地塞米松灌肠辅助治疗活动期溃疡性结肠炎患者的效果及对炎症因子水平的影响。方法选取景德镇市第一人民医院2021年1月至2022年5月收治的68例活动期溃疡性结肠炎患者作为研究对象,按照抽签法将其分为对照组(n=34)和观察组(n=34),对照组患者使用美沙拉嗪治疗,观察组加用地塞米松灌肠辅助治疗,比较两组患者治疗效果、炎症因子、Mayo评分、不良反应发生率。结果观察组患者治疗总有效率为94.12%,高于对照组的73.53%,差异有统计学意义(P<0.05)。观察组患者治疗后C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)水平均低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后Mayo评分及Geboes指数低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论地塞米松灌肠辅助治疗活动期溃疡性结肠炎患者,能明显抑制患者炎症反应,减轻氧化应激反应,促进肠黏膜愈合,提高临床疗效。
Objective To investigate the therapeutic effect of Dexamethasone enema adjuvant therapy on patients with active ulcerative colitis and the effect on the level of inflammatory factors.Methods A total of 68 patients with active ulcerative colitis admitted to Jingdezhen NO.1 People's Hospital from January 2021 to May 2022 were selected as research objects.All the patients were divided into control group(n=34)and observation group(n=34)according to the lottery method.The control group was treated with Mesalazine,and the observation group was treated with Dexamethasone enema.Therapeutic efficacy,inflammatory factors,Mayo score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of observation group was 94.12%,which was higher than that of control group(73.53%),and the difference was statistically significant(P<0.05).The levels of C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in control group after treatment,and the differences were statistically significant(P<0.05).Mayo score and Geboes index in observation group were lower than those in control group after treatment,the differences were statistically significant(P<0.05).There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Dexamethasone enema adjuvant therapy for patients with active ulcerative colitis can significantly inhibit inflammatory response,reduce oxidative stress response,promote intestinal mucosal healing and improve clinical efficacy.
作者
万文明
汪福昌
吴娟
WAN Wenming;WANG Fuchang;WU Juan(Department of Gastroenterology,Jingdezhen NO.1 People's Hospital,Jiangxi Province,Jingdezhen333000,China)
出处
《中国当代医药》
CAS
2023年第13期50-53,共4页
China Modern Medicine
基金
江西省卫生健康委科技计划项目(SKJP220218690)。
关键词
地塞米松
灌肠
活动期溃疡性结肠炎
炎症因子
疗效
Dexamethasone
Enema
Active ulcerative colitis
Inflammatory factors
Therapeutic effect
