摘要
目的:评价蓝芩口服液联合阿奇霉素治疗小儿肺炎支原体肺炎毒热闭肺证的疗效。方法:将符合入选标准的2017年1月-2019年1月本院82例肺炎支原体肺炎患儿,按随机数字表法分为2组,每组41例。在西医常规治疗基础上对照组给予阿霉素序贯疗法,观察组在对照组基础上给予蓝芩口服液。2组均治疗7 d。分别于治疗前后进行症状、体征评分,采取ELISA法检测血清IL-6、TNF-α水平,观察并记录退热、咳嗽消失、干湿啰音消失及喘息消失时间,记录治疗期间的不良反应,评价临床疗效。结果:观察组总有效率为95.1%(39/41)、对照组为75.6%(31/41),2组比较差异有统计学意义(χ2=4.783,P=0.029)。观察组患儿退热、咳嗽消失、干湿啰音消失及喘息消失时间均明显早于对照组(t值分别为9.312、8.740、7.350、12.467,P值均<0.001)。观察组治疗后咳嗽、发热、喘息、口渴、痰黄稠难咳评分均低于对照组(t值分别为14.350、16.779、18.005、17.441、23.633,P值均<0.001)。观察组治疗后血清IL-4[(12.56±1.80)ng/L比(17.09±2.78)ng/L,t=8.758]、TNF-α[(14.08±2.15)ng/L比(20.04±2.93)ng/L,t=10.501]水平均低于对照组(P<0.01)。治疗期间,对照组不良反应发生率为17.07%(7/41)、观察组为19.51%(8/41),2组比较差异无统计学意义(P>0.05)。结论:蓝芩口服液联合阿奇霉素可有效改善肺炎支原体肺炎患儿的临床症状,降低血清IL-4、TNF-α水平,提高临床疗效,且安全性较好。
Objective To evaluate the efficacy of Lanqin oral liquid combined with Azithromycin in treating mycoplasma pneumoniae pneumonia children with syndrome of heat-toxicity blocking lung.Methods A total of 82 children with mycoplasma pneumoniae from January of 2017 to January of 2019 who met the inclusion criteria were divided into two groups according to the random number table method with 41 patients in each group.The control group was given with Azithromycin sequential therapy,and the observation group was given with Lanqin oral liquid on the basis of conventional western medicine.Both groups were treated for 7 days.Scores of symptoms and signs were evaluated before and after treatment,serum levels of IL-4 and tumor necrosis TNF-αwere detected by ELISA method,the disappearance time of fever,cough,dry and wet ralogue and wheezing were observed and recored,adverse reactions occurred during treatment were recorded,and the clinical efficacy was evaluated.Results The total effective rate of the observation group and the control group was 95.1%(39/41)and 75.6%(31/41),respectively,and the difference was statistically significant(χ2=4.783,P=0.029).The antipyretic time,cough disappearance time,dry and wet ralogue disappearance time,and wheezing disappearance time of the observation group were significantly shorter than those of the control group(t=9.312,8.740,7.350,12.467,respectively,all Ps<0.001).After treatment,the scores of cough,fever,wheezing,thirst,phlegm yellow thick and difficultly coughing in the observation group were significantly lower than those in the control group(t=14.350,16.779,18.005,17.441,23.633,respectively,all Ps<0.001).After treatment,the scores of cough,fever,wheezing,thirst,yellow thick phlegm and difficultly in coughing in the observation group were significantly lower than those in the control group(t=14.350,16.779,18.005,17.441,23.633,respectively,all Ps<0.001).After treatment,serum levels of IL-4(12.56±1.80 ng/L vs.17.09±2.78 ng/L,t=8.758)and TNF-α(14.08±2.15 ng/L vs.20.04±2.93 ng/L,t=10
作者
于德娇
杨柳
徐丽丽
李海霞
Yu Dejiao;Yang Liu;Xu Lili;Li Haixia(Department of Paediatrics,Yantai Affiliated Hospital of Binzhou Medical University,Yantai 264100,China;Hand Surgery and Microsurgery,Foot and Ankle Surgery,Yantai Affiliated Hospital of Binzhou Medical University,Yantai 264100,China)
出处
《国际中医中药杂志》
2020年第10期964-967,共4页
International Journal of Traditional Chinese Medicine
关键词
肺炎
支原体
热毒闭肺
蓝芩口服液
阿奇霉素
白细胞介素6
肿瘤坏死因子-α
Pneumonia,mycoplasma
Heat toxin blocking lung
Lanqin oral liquid
Azithromycin
Interleukin-6
Tumor Necrosis Factor-alpha
