摘要
目的系统评价冠状动脉内注射尼可地尔对急性心肌梗死(AMI)患者首次经皮冠状动脉介入治疗(PCI)术后无复流现象(NR)的疗效。方法计算机检索PubMed、Cochrane Library、Wily Online Library、Embase、中国知网、万方数据知识服务平台、维普等数据库,收集建库至2019年7月1日发表的关于冠状动脉内注射尼可地尔治疗AMI患者首次PCI术后NR的随机对照试验(RCT)研究。采用RevMan5.3软件进行meta分析。结果共纳入7篇RCT,涉及739例患者。meta分析结果显示:尼可地尔组NRP或慢血流发生率、校正的TIMI帧数(cTFC)、左心室射血分数(LVEF)及恶性心律失常发生率明显优于对照组,差异均有统计学意义(P<0.05)。结论PCI术前冠状动脉内注射尼可地尔可降低AMI患者术后NRP发生率和cTFC数值,提高患者术后LVEF水平,并降低术后恶性心律失常发生率。
Objective To systematically evaluate the efficacy of intracoronary nicorandil injection on no-reflow phenomenon(NRP)in patients with acute myocardial infarction(AMI)after first percutaneous coronary intervention(PCI).Methods PubMed,Cochrane Library,Wily Online Library,Embase,CNKI,Wanfang Data Knowledge Service Platform,VIP database were searched by computer.Randomized controlled trials(RCT)studies of intracoronary nicorandil injection in the treatment of NR in patients with AMI after first PCI from the establishment of the database to July 1,2019 were collected.RevMan5.3 software was used for meta-analysis.Results Seven RCTs involving 739 patients were included.Meta analysis showed that,the incidence of NRP or slow flow,corrected TIMI frame number(cTFC),left ventricular ejection fraction(LVEF)and incidence of malignant arrhythmia in the nicorandil group were significantly better than those in the control group(P<0.05).Conclusion Intracoronary injection of nicorandil before PCI can reduce the incidence of NRP and cTFC,improve the level of LVEF and reduce the incidence of malignant arrhythmia.
作者
刘嘉馨
李芝峰
LIU Jiaxin;LI Zhifeng(Department of Cardiology,Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China)
出处
《现代医药卫生》
2020年第22期3566-3570,共5页
Journal of Modern Medicine & Health
