摘要
目的:探讨血管紧张素Ⅱ受体拮抗剂(ARB)对防治冠状动脉介入术后造影剂肾病的有效性,为临床防治造影剂肾病提供新思路。方法:将2006年9月—2010年8月行冠状动脉介入治疗的冠心病患者525例随机分为观察组和对照组。两组分别于应用造影剂前、后口服缬沙坦或安慰剂每日1次。比较两组造影后48h及5天时相关临床指标变化。结果:应用造影剂后48h及5天的观察结果显示,观察组24h尿蛋白和肾小球滤过率均显著优于对照组,两组比较差异有统计学意义(P<0.05)。结论:ARB对冠状动脉介入术后造影剂肾病具有一定的保护作用。
Objective ：To study the effect of ARB on contrast induced nephrotoxity after percutaneous coronary intervention, and find out a new clinical method for prevention and treatment of contract - induced nephrotoxity.
Methods：525 coronary heart disease of 525 cases which received treafment with percutaneous coronary intervention from September 2006 to August 2010 were rrandomly divided into the observation group and the control group. The patients in the two groups received volsartan or placebo orally once a day before and after contrast media application, respectively To compare variation of clinital parameters 48 - hour and S - day contrast media application.
Results：The patients in observation group showed better results than that in control group 48 - hour and 5 - day after contrast media application, which had significant difference （ P 〈 0.05 ）.
Conclusion ： ARB has a certain degree of protection role for contrast induced nephrotity after percutaneous coronary intervention.
出处
《新疆医学》
2011年第1期9-11,共3页
Xinjiang Medical Journal
