摘要
中枢神经类疾病是一种进行性疾病,起病具有隐匿性,造成的人体伤害后果严重,对个人和社会造成了沉重的负担。当前这类疾病的诊断高度依赖于临床症状,缺乏可用于早期诊断的生物标志物。代谢组学是继基因组学、表观基因组学、转录组学、蛋白质组学之后最新的系统生物学平台,涵盖了100~1000 Da完整的代谢产物/低分子量中间体(代谢组)的轮廓,为疾病的早期诊断和标志物的发现提供了广阔的前景,有望为中枢神经类疾病提供新的、早期的、具有生物学和临床意义的标志物。本文综述了代谢组学技术在常见中枢性神经疾病(阿尔茨海默病、抑郁症、帕金森病)研究中的应用。
Central nervous system diseases are progressive,insidious onset,and have serious consequences.It has caused a heavy burden on individuals and society.However,the current diagnosis of these diseases is highly dependent on their clinical symptoms and lack of markers that can be used for early diagnosis.Metabolomics is the latest systems biology platform after genomics,epigenomics,transcriptomics,and proteomics.It covers the outline of 100-1000 Da complete metabolites.The early diagnosis of diseases and the discovery of markers provide broad prospects,which are expected to provide new,early,biological and clinical markers for central nervous system diseases.The following reviews the application of metabolomics techniques in common central nervous diseases(Alzheimer’s disease,depression,Parkinson’s disease).
作者
郎金雨
王耀
甄百新
热依汉古丽
董屿
魏斌斌
LANG Jinyu;WANG Yao;ZHEN Baixin;Reyihanguli;DONG Yu;WEI Binbin(School of China Medical University,Pharmacy,Shenyang 110021,China)
出处
《沈阳医学院学报》
2020年第6期579-582,586,共5页
Journal of Shenyang Medical College
基金
2019年中国医科大学大学生创新创业训练计划资助项目(No.201910159082)
国家自然科学基金(No.81703519)。
关键词
代谢组学
阿尔茨海默病
抑郁症
帕金森病
metabolomics
Alzheimer’s disease
depression
Parkinson’s disease
