摘要
异丙酚是一种在心脏手术中常用的脂溶性静脉麻醉药,具有与抗氧化剂维生素E类似的化学结构。体内外研究证实,异丙酚主要通过减轻氧化应激和炎症反应、保护线粒体功能及抑制细胞凋亡来对抗缺血/再灌注诱导的心肌损伤。此外,异丙酚还可以改善心肌缺血/再灌注后的血管内皮功能。然而,异丙酚应用于临床时对心肌缺血/再灌注损伤患者的心肌保护作用欠佳。异丙酚与气体麻醉药或抗氧化剂联合应用时对心肌缺血/再灌注损伤的防治效果可以加强。本文就异丙酚对心肌缺血/再灌注损伤的保护作用及机制进行综述。
Propofol is a fat-soluble intravenous anesthetic commonly used in heart surgery and has a chemical structure similar to the antioxidant vitamin E.In vitro and in vivo studies have demonstrated that propofol fights ischemia/reperfusion-induced myocardial injury primarily by mitigating oxidative stress and inflammatory responses,protecting mitochondrial function,and inhibiting apoptosis.In addition,propofol can improve endothelial function after myocardial ischemia/reperfusion.However,clinically,propofol has poor cardioprotection in patients with myocardial ischemia/reperfusion injury.Propofol can be combined with gas anesthetics or antioxidants to prevent and treat myocardial ischemia/reperfusion injury.This article summaries the roles and mechanisms of propofol in protecting myocardium against ischemia/reperfusion injury.
作者
韩荣辉(综述)
夏正远(审校)
HAN Rong-hui;XIA Zheng-yuan(Department of Anesthesiology,the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,CHINA)
出处
《海南医学》
CAS
2020年第21期2796-2799,共4页
Hainan Medical Journal
基金
国家自然科学基金(编号:81670770)。
关键词
心肌缺血/再灌注损伤
异丙酚
心肌保护
抗氧化
联合用药
Myocardial ischemia/reperfusion injury
Propofol
Cardioprotection
Anti-oxidation
Combined medication
