摘要
结肠癌是常见的消化道恶性肿瘤,其手术部位感染(SSI)是结肠癌术后常见并发症之一。随着高通量测序技术的快速发展,使肠道菌群与SSI的关系越来越被重视。本文将对近几年相关研究进展进行回顾,基于细菌在SSI中的作用,从不同手术方式的选择、机械肠道准备和(或)特定抗生素的应用对肠道菌群产生的影响出发,深入探讨结肠癌术前肠道准备的价值、不同手术方式选择的区别对肠道菌群的影响,以及可能在术后SSI上的作用,旨在更全面地认识肠道菌群对结肠癌术后SSI作用的机制,并能予以相应有效的预防措施,为临床实践提供新的思路。
Colon cancer is a common malignant tumor of digestive tract.Surgical site infection(SSI),is one of the common postoperative complications of colon cancer.With the rapid development of high-throughput sequencing technology,people pay more and more attention to the relationship between intestinal microflora and SSI.The progress of related researches in recent years were reviewed in detail.Based on the role of bacteria in SSI and the influence of surgical mode,mechanical intestinal preparation and/or use of specific antibiotics on emergence of intestinal flora,the value of the preoperative intestinal preparation was further explored,the influence of the surgical mode on intestinal flora was observed,the effect on the postoperative SSI was analyzed.It is designed to comprehensively understand the mechanism of intestinal flora on postoperative SSI in the colon cancer patients,take targeted and effective prevention measures and provide guidance for clinical practice.
作者
曹云
张熔熔
袁晓敏
刘海霞
王强
CAO Yun;ZHANG Rong-rong;YUAN Xiao-min;LIU Hai-xia;WANG Qiang(Jiang Yan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine,Taizhou,Jiangsu 225500,China,China;不详)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2020年第20期3196-3200,共5页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(81673795)。
关键词
肠道菌群
结肠癌手术
手术部位感染
肠道准备
Intestinal flora
Colon cancer surgery
Surgical site infection
Bowel preparation
