摘要
钙防卫蛋白是由S100A8及S100A9蛋白以钙离子依赖性方式组成的异源二聚体,能够调控细胞的增殖、分化以及凋亡,在感染及肿瘤的发生发展过程中发挥重要作用。S100A8/A9在大多头颈部肿瘤组织中低表达,通过以蛋白磷酸酶2α依赖的方式阻断细胞周期G2/M检查点,进而抑制癌细胞的增殖,发挥重要的抑癌作用。S100A8/A9在头颈部肿瘤组织中的低表达与鳞状细胞分化不良、表皮生长因子受体表达上调、DNA甲基化水平的增强以及肿瘤患者生存率的降低密切相关。
Calprotectin is a calcium-dependent heterodimer composed of S100 A8 and S100 A9 proteins,which can regulate cell proliferation,differentiation and apoptosis,and play an important role in infection,tumorigenesis and so on.S100 A8/A9 is low expressed in most head and neck tumor tissues and plays an important anti-cancer role by arresting at the G2/M checkpoint of cell cycle in a protein phosphatase-2α dependent manner,thereby inhibiting the proliferation of cancer cells.The low expression of S100 A8/A9 in head and neck tumor tissues is closely associated with poor squamous cell differentiation,upregulation of epidermal growth factor receptor,enhanced DNA methylation,and reduced survival rate of the tumor patients.
作者
冀慎英
张湘豫
邹先琼
JI Shenying;ZHANG Xiangyu;ZOU Xianqiong(Institute of Stomatological Medicine,Affiliated Stomatology Hospital of Guilin Medical University,Guilin 541004,China;College of Basic Medicine,Guilin Medical University,Guilin 541100,China)
出处
《医学综述》
2020年第21期4235-4240,共6页
Medical Recapitulate
基金
国家自然科学基金(81760490)
广西自然科学基金(2017GXNSFAA198239)。
