摘要
帕金森病(Parkinson’s disease,PD)是中枢神经系统第二大退行性疾病。目前认为PD与年龄、性别、家族遗传、基因突变和环境等因素有关。PD发病机制复杂,与多巴胺能神经元功能障碍和丢失有关,涉及α-突触核蛋白积聚、神经炎症、氧化应激、线粒体功能障碍、神经黑色素过度累积等多方面,各种因素既独立发挥作用又相互交叉促进,构成脑组织损伤的恶性循环,表现为PD病理的不断进展。本文就近年来PD致病因素和发病机制方面的研究作一综述,为PD治疗和药物研发探索新的思路和潜在靶点。
Parkinson’s disease(PD)is the second most common neurodegenerative disease of the central nervous system.It is currently believed that PD is related to factors such as age,gender,family inheritance,gene mutation and environment.The pathogenesis of PD is complex and is related to dysfunction and loss of dopaminergic neurons,involving accumulation ofα-synuclein,neuroinflammation,oxidative stress,mitochondrial dysfunction and excessive accumulation of neuromelanin.In many ways,various factors act both independently and through cross-promotion,resulting in an ongoing pattern of brain tissue damage and progressing PD pathology.This article reviews the recent research on the pathogenic factors and pathogenesis of PD and explores new ideas and potential targets for PD treatment and drug development.
作者
张森
赵晓悦
梁宇
李莎
杜冠华
ZHANG Sen;ZHAO Xiao-yue;LIANG Yu;LI Sha;DU Guan-hua(Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《药学学报》
CAS
CSCD
北大核心
2020年第10期2264-2272,共9页
Acta Pharmaceutica Sinica
基金
国家科技重大专项重大新药创制(2018ZX09711001-012,003-019)
中国医学科学院医学与健康科技创新工程(2016-I2M-3-007,2017-I2M-1-010)。
关键词
帕金森病
致病因素
发病机制
治疗药物
Parkinson’s disease
pathogenic factor
pathogenesis
therapeutic drug
