摘要
目的探讨分析氟西汀联合莫沙必利对结直肠癌术后患者焦虑抑郁情绪及胃肠功能的影响。方法选取2017年1月~2018年12月我院收治的300例结直肠癌术后患者作为研究对象,采用随机数字表法进行分组,对照组150例患者给予莫沙必利口服治疗,观察组150例患者在对照组基础上联合氟西汀治疗,观察对比两组患者治疗后肠鸣音次数、肛门排气时间、排便时间和胃肠激素水平、焦虑抑郁情绪变化,并对比治疗临床效果及安全性。结果观察组术后肛门排气时间、排便时间低于对照组,5d肠鸣音次数高于对照组;观察组患者术后血清生长抑素(SS)水平低于对照组,胃动素(MTL)水平高于对照组;观察组患者术后的HAMD、HAMA评分低于对照组;观察组患者治疗总有效率高于对照组(P<0.05);两组患者用药期间不良反应发生率差异无统计学意义(P>0.05)。结论氟西汀联合莫沙必利能够有效缓解结直肠癌术后患者焦虑抑郁情绪,促进胃肠功能恢复,安全性高。
Objective To analyze the effect of fluoxetine combined with mosabili on psychological state and gastrointestinal function of postoperative patients with colorectal cancer Methods A total of 300 postoperative patients with colorectal cancer in our hospital from January 2017 to December 2018 were collected and randomly divided into two groups:control group(150 patients)received mosapride,observation group(150 cases)received fluoxetine,routine body position nursing.150 patients in the control group were treated with Mosapride,150 patients in the observation group were combined with fluoxetine on the basis of the control group.The number of bowel sounds,anal exhaust time,defecation time,gastrointestinal hormone levels,anxiety and depression mood before and after treatment and clinical efficacy and safety in the two groups were compared.Results After treatment,the anal exhaust time and defecation time in the observation group were lower than those in the control group,and the frequency of bowel sounds was higher than that in the control group on the 5 th day.The level of serum somatostatin(SS)in the observation group was lower than that in the control group,and the level of motilin(MTL)was higher than that in the control group.HAMD and HAMA scores in the observation group were lower than that in the control group.The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions in the two groups(P>0.05).Conclusion Fluoxetine c ombined with mosapride can effectively alleviate the anxiety and depression postoperative patients with colorectal cancer,and promote the recovery of gastrointestinal function,which has a high safety.
作者
王雁军
王青兵
张勇
WANG Yanjun;WANG Qingbing;ZHANG Yang(Anyang Cancer Hospital,Anyang 455000,China)
出处
《国际精神病学杂志》
2020年第5期1035-1038,共4页
Journal Of International Psychiatry
关键词
氟西汀
莫沙必利
结直肠癌术后
焦虑抑郁
胃肠功能
Fluoxetine
Mosapride
Postoperative colorectal cancer
Anxiety and depression
Gastrointestinal function
