摘要
特发性肺纤维化(IPF)是以肺泡上皮细胞损伤和成纤维细胞增生为特征的一类间质性肺疾病,患者的中位生存期仅为2~3年。近年来,程序性坏死作为可调控的坏死类型,被认为是介导炎症和纤维化的重要因素。最近研究发现了程序性坏死不仅参与了吸烟加速IPF的进展,还被证明了其与家族性IPF的发生有关,从而成为了研究IPF发生和发展的热点。文章主要就程序性坏死的发生机制及其参与IPF发生发展的研究进展进行综述。
Idiopathic pulmonary fibrosis(IPF)is a type of interstitial lung disease characterized by alveolar epithelial cell injury and fibroblast proliferation.The median survival of patients is only 2 to 3 years.In recent years,necroptosis,as controllable necrosis type,has been regarded as an important factor mediating inflammation and fibrosis.Recent studies have found that programmed necrosis not only involved in smoking to accelerate the progress of IPF,but also has been proved to be related to the occurrence of familial IPF,which has become a hot spot in the research on the occurrence and development of IPF.This article reviews the research advance in the mechanism of necroptosis and its involvement in the development of IPF.
作者
李思佳
李文新(综述)
宋新宇(审校)
LI Si-jia;LI Wen-xin;SONG Xin-yu(The Second Department of Respiratory and Critical Care Unit,the First College of Clinical Science,China Three Gorges University/Yichang Central People's Hospital,Yichang 443003,Hubei,China)
出处
《医学研究生学报》
CAS
北大核心
2020年第11期1218-1222,共5页
Journal of Medical Postgraduates
基金
湖北省卫生计生委科研项目(WJ2019M062)。
关键词
特发性肺纤维化
程序性坏死
炎症
纤维化
idiopathic pulmonary fibrosis
necroptosis
inflammation
fibrosis
