摘要
目的分析维持性血液透析(maintenance hemodialysis,MHD)患者血镁现状,探讨血镁影响因素及其与心脑血管事件的关系。方法筛选2018年3月在南通大学附属医院血液透析中心常规接受MHD治疗的126名患者,收集患者基本资料、临床指标,随访24个月,每6个月评估并且记录患者一般性情况及临床指标。结果126名患者中血镁正常组[(1.01±0.08)mmol/L]50例,高镁血症组[(1.27±0.16)mmol/L]76例,无低镁血症患者。多因素Logistic回归分析显示,血清白蛋白较高(OR=2.020,95%CI 1.497~2.727,P<0.001)、超敏C反应蛋白较低(OR=0.904,95%CI 0.824~0.992,P=0.034)的MHD患者血镁水平更高。多因素COX比例风险模型显示血镁水平低是心脑血管事件的独立危险因素(HR=7.461,95%CI 2.005~27.766,P=0.003)。结论MHD患者中血镁较高者其营养状态好,炎症水平低,且心脑血管事件患病风险低于正常血镁患者。MHD治疗患者维持轻度高镁水平可能获益更多。
Objective The study was to analyze the current situation of serum magnesium(Mg)in maintenance hemodialysis(MHD)patients,the influencing factors for serum Mg level,and the relationship between serum Mg and cardio-cerebrovascular events.Methods We analyzed 126 patients treated with MHD in March 2018 at the Blood Purification Center,the Affiliated Hospital of Nantong University.And they were followed up for 24 months.Results Multivariate logistic regression analysis showed that patients with higher serum albumin(OR=2.020,95%CI:1.497~2.727,P<0.001)and lower high-sensitivity C-reactive protein(OR=0.904,95%CI:0.824~0.992,P=0.034)had higher serum Mg level.Multivariate COX proportional hazard analysis showed that lower serum Mg was the independent risk factor for adverse cardio-cerebrovascular events(HR=7.461,95%CI:2.005~27.766,P=0.003).Conclusions MHD patients with hypermagnesemia had better nutritional status,lower inflammatory level,and lower risk of cardio-cerebrovascular events than patients with normal serum Mg.Therefore,maintenance of serum Mg at a slightly higher level may be beneficial for MHD patients.
作者
王熙坚
祁月
张叶
张光第
刘静
陈晓岚
戴厚永
WANGXi-jian;QI Yue;ZHANG Ye;ZHANG Guang-di;LIU Jing;CHEN Xiao-lan;DAI Hou-yong(Department of Nephrology,the Affiliated Hospital of Nantong University,Nantong 226001,China)
出处
《中国血液净化》
CSCD
2020年第11期747-750,共4页
Chinese Journal of Blood Purification
关键词
维持性血液透析
血镁
心脑血管事件
Maintenance hemodialysis
Serum magnesium
Cardio-cerebrovascular event
